Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 4/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | ACHE | P22303 | 1/20 | 0.32 |
| ▸ | TAS2R14 | Q9NYV8 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.31 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | STAT3 | P40763 | 1/20 | 0.31 |
| ▸ | PPID | Q08752 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6712432 | 0.90 | MAPK1 (0.38) | POLBALDH1A1KMT2AMEN1TP53 | |
| SCHEMBL6709476 | 0.88 | MAPT (0.46) | POLBALDH1A1KMT2ANPSR1MEN1 | |
| SCHEMBL7321027 | 0.86 | CYP2D6 (0.34) | ALDH1A1NPSR1TP53MAPK1ALOX15 | |
| SCHEMBL7318412 | 0.86 | ALDH1A1 (0.37) | POLBALDH1A1KMT2AMEN1SMN1; SMN2 | |
| SCHEMBL7174955 | 0.84 | KMT2A (0.42) | ALDH1A1KMT2ANPSR1MEN1TP53 | |
| SCHEMBL6714501 | 0.83 | CA9 (0.38) | POLBALDH1A1KMT2AMEN1MAPT | |
| SCHEMBL6708265 | 0.81 | ALDH1A1 (0.44) | POLBALDH1A1KMT2ANPSR1MEN1 | |
| SCHEMBL6714697 | 0.81 | CA1 (0.33) | POLBALDH1A1KMT2AMEN1MAPT | |
| SCHEMBL3855348 | 0.80 | MMP2 (0.33) | KMT2A | |
| SCHEMBL7421577 | 0.79 | MMP9 (0.37) | POLBALDH1A1KMT2AMEN1TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6583139-B1 | Treatment of inflammatory diseases; inflammatory brain diseases such as multiple sclerosis; N-(Toluene-4-sulfonyl)-L-prolyl-4-(alpha -methylbenzyloxy)-L-phenylalanine; Very Late Antigen 4 | BIOGEN IDEC INTERNATIONAL HOLDING LTD. (BM) | 2003-06-24 | — | — | US | claimed |