Sugi Predict

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Lithium

Lithium

SCHEMBL7189944

Cc1ccc(C)c(PC(=O)c2c(C)cccc2Cl)c1.[Li]

nearest known ligand 0.39

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ TYK2 P29597 1/20 0.39
▸ PTGS2 P35354 2/20 0.37
▸ FABP3 P05413 1/20 0.36
▸ FABP4 P15090 1/20 0.36
▸ ALDH1A1 P00352 1/20 0.36
▸ GAA P10253 3/20 0.36
▸ POLB P06746 1/20 0.36
▸ MAPT P10636 1/20 0.35
▸ ALDH2 P05091 1/20 0.35
▸ HCRTR1 O43613 1/20 0.34
▸ HCRTR2 O43614 1/20 0.34
▸ RAB9A P51151 2/20 0.34
▸ ITGB1 P05556 3/20 0.34
▸ ITGA4 P13612 3/20 0.34
▸ ITGA2 P17301 1/20 0.34
▸ ITGB7 P26010 1/20 0.34
▸ S1PR4 O95977 1/20 0.33
▸ HDAC4 P56524 1/20 0.33
▸ ABCB1 P08183 1/20 0.33
▸ TRPM4 Q8TD43 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7189939 0.97 TYK2 (0.39) TYK2PTGS2FABP3FABP4ALDH1A1
Lithium SCHEMBL7177510 0.96 ALDH1A1 (0.39) TYK2PTGS2FABP3FABP4ALDH1A1
SCHEMBL10870076 0.94 ALDH1A1 (0.40) TYK2PTGS2FABP3FABP4ALDH1A1
SCHEMBL7177506 0.93 ALDH1A1 (0.39) TYK2PTGS2FABP3FABP4ALDH1A1
Lithium SCHEMBL7180693 0.90 S1PR4 (0.38) ALDH1A1GAAS1PR4
Lithium SCHEMBL7183080 0.89 TYK2 (0.39) TYK2PTGS2FABP3FABP4ALDH1A1
Lithium SCHEMBL7187695 0.87 MEN1 (0.40) FABP4ALDH1A1GAAMAPTRAB9A
SCHEMBL7180684 0.86 S1PR4 (0.38) ALDH1A1GAAS1PR4
SCHEMBL7183079 0.86 TYK2 (0.39) TYK2PTGS2FABP3FABP4ALDH1A1
Lithium SCHEMBL7182848 0.85 FABP3 (0.43) TYK2PTGS2FABP3FABP4ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6579663-B2 Chemical intermediates such as lithium 2,6-dimethylbenzoyl phenylphosphine for preparation of acylphosphines, acylphosphine oxides or acylphosphine sulfides CIBA SPECIALTY CHEMICALS CORPORATION 2003-06-17 — — US disclosed
US-20020107413-A1 Organometallic monoacylarylphosphines WOLF JEAN-PIERRE (CH) 2002-08-08 — — US disclosed
US-6399805-B2 SUCH AS LITHIUM 2,6-DIMETHYLBENZOYLPHENYLPHOSPHINE, USE AS PHOTOINITIATORS IN PHOTOCURABLE COMPOSITIONS SUCH AS FOR PHOTOGRAPHIC PRODUCTION OF RELIEF IMAGES CIBA SPECIALTY CHEMICALS CORPORATION 2002-06-04 — — US disclosed
US-20010031898-A1 Organometallic monoacylarylphosphines CIBA SPECIALTY CHEMICALS CORP. 2001-10-18 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20020107413-A1 Organometallic monoacylarylphosphines CBR1, NAF1, DHCR24 TYK2 1285/4885PTGS2 3909/4885FABP3 3252/4885
US-20010031898-A1 Organometallic monoacylarylphosphines NAF1, DHCR24, CBR1 TYK2 1333/4885PTGS2 3871/4885FABP3 2807/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.