Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB2 | P07550 | 9/20 | 0.53 |
| ▸ | ADRB1 | P08588 | 3/20 | 0.53 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.53 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.53 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.53 |
| ▸ | BLM | P54132 | 1/20 | 0.51 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.39 |
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.38 |
| ▸ | CXCL8 | P10145 | 1/20 | 0.37 |
| ▸ | CTSA | P10619 | 1/20 | 0.36 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.36 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL250027 | 0.79 | ESR1 (0.46) | ADRB2ADRB1SLC6A2SLC6A4 | |
| SCHEMBL31444515 | 0.74 | CTSS (0.42) | ADRB2ADRB1CYP2D6NFKB1HIF1A | |
| SCHEMBL13950520 | 0.74 | ADRB2 (0.50) | ADRB2ADRB1CYP2D6NFKB1HIF1A | |
| SCHEMBL13306842 | 0.74 | CTSS (0.42) | ADRB2ADRB1CYP2D6NFKB1HIF1A | |
| SCHEMBL10216878 | 0.74 | CTSS (0.42) | ADRB2ADRB1CYP2D6NFKB1HIF1A | |
| SCHEMBL17788592 | 0.74 | ADRB2 (0.50) | ADRB2ADRB1CYP2D6NFKB1HIF1A | |
| SCHEMBL10245333 | 0.74 | RIPK1 (0.54) | ADRB2ADRB1SLC6A4RIPK1 | |
| SCHEMBL10245495 | 0.74 | RIPK1 (0.54) | ADRB2ADRB1SLC6A4RIPK1 | |
| SCHEMBL7751173 | 0.74 | RIPK1 (0.54) | ADRB2ADRB1SLC6A4RIPK1 | |
| SCHEMBL4975907 | 0.74 | ADRB2 (0.44) | ADRB2ADRB1CYP2D6NFKB1HIF1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6624181-B1 | Synergistic combination | ALTANA PHARMA AG (DE) | 2003-09-23 | — | — | US | claimed |
| US-6624181-B1 | Synergistic combination | ALTANA PHARMA AG (DE) | 2003-09-23 | — | — | US | disclosed |