Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 7/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | LSS | P48449 | 2/20 | 0.43 |
| ▸ | LIPE | Q05469 | 2/20 | 0.42 |
| ▸ | SRD5A1 | P18405 | 3/20 | 0.41 |
| ▸ | RAB9A | P51151 | 3/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.36 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.36 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.36 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7201224 | 0.84 | SMN1; SMN2 (0.52) | KCNH2SMN1; SMN2MAPTLMNAL3MBTL1 | |
| SCHEMBL3365485 | 0.83 | SMN1; SMN2 (0.49) | SMN1; SMN2MAPTLMNAL3MBTL1LSS | |
| SCHEMBL3368384 | 0.81 | SMN1; SMN2 (0.51) | SMN1; SMN2MAPTLMNAL3MBTL1LSS | |
| SCHEMBL3365632 | 0.74 | SMN1; SMN2 (0.56) | SMN1; SMN2MAPTLMNAL3MBTL1LIPE | |
| SCHEMBL3369187 | 0.73 | MAPT (0.53) | KCNH2SMN1; SMN2MAPTLMNAL3MBTL1 | |
| SCHEMBL7204877 | 0.73 | LSS (0.76) | KCNH2LSS | |
| SCHEMBL7178386 | 0.73 | THRA (0.47) | SMN1; SMN2LMNALSSLIPENPC1 | |
| SCHEMBL3363725 | 0.72 | LSS (0.55) | SMN1; SMN2MAPTLMNAL3MBTL1LSS | |
| SCHEMBL7173887 | 0.72 | LIPE (0.48) | SMN1; SMN2LMNALSSLIPESRD5A1 | |
| SCHEMBL3365198 | 0.72 | LSS (0.57) | SMN1; SMN2MAPTLMNAL3MBTL1LSS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1303503-A2 | ANILINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2003-04-23 | — | — | EP | disclosed |
| WO-2002006189-A2 | ANILINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2002-01-24 | — | — | WO | disclosed |