Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | FDPS | P14324 | 2/20 | 0.46 |
| ▸ | LIPE | Q05469 | 2/20 | 0.46 |
| ▸ | LSS | P48449 | 1/20 | 0.45 |
| ▸ | THRA | P10827 | 2/20 | 0.44 |
| ▸ | THRB | P10828 | 2/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.43 |
| ▸ | BLM | P54132 | 1/20 | 0.43 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7178386 | 0.88 | THRA (0.47) | SMN1; SMN2LMNAFDPSLIPELSS | |
| SCHEMBL3365632 | 0.88 | SMN1; SMN2 (0.56) | SMN1; SMN2MAPTLMNAL3MBTL1LIPE | |
| SCHEMBL3369187 | 0.87 | MAPT (0.53) | SMN1; SMN2MAPTLMNAL3MBTL1LIPE | |
| SCHEMBL3363725 | 0.85 | LSS (0.55) | SMN1; SMN2MAPTLMNAL3MBTL1LIPE | |
| SCHEMBL3365198 | 0.84 | LSS (0.57) | SMN1; SMN2MAPTLMNAL3MBTL1LSS | |
| SCHEMBL7173887 | 0.84 | LIPE (0.48) | SMN1; SMN2LMNALIPELSSTHRA | |
| SCHEMBL7192259 | 0.84 | KCNH2 (0.49) | SMN1; SMN2MAPTLMNAL3MBTL1LIPE | |
| SCHEMBL3365622 | 0.83 | LSS (0.56) | SMN1; SMN2MAPTLMNAL3MBTL1LIPE | |
| SCHEMBL3366751 | 0.83 | SMN1; SMN2 (0.60) | SMN1; SMN2MAPTLMNAL3MBTL1LIPE | |
| SCHEMBL7169877 | 0.83 | THRA (0.51) | LSSTHRATHRBTP53TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1303503-A2 | ANILINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2003-04-23 | — | — | EP | disclosed |
| WO-2002006189-A2 | ANILINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2002-01-24 | — | — | WO | disclosed |