Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APEX1 | P27695 | 2/20 | 1.00 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | CA12 | O43570 | 7/20 | 0.46 |
| ▸ | CA2 | P00918 | 7/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | PGR | P06401 | 1/20 | 0.43 |
| ▸ | ALPL | P05186 | 1/20 | 0.41 |
| ▸ | ALPI | P09923 | 1/20 | 0.41 |
| ▸ | AHR | P35869 | 1/20 | 0.40 |
| ▸ | CA1 | P00915 | 1/20 | 0.40 |
| ▸ | CA9 | Q16790 | 1/20 | 0.40 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.40 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11849091 | 0.80 | APEX1 (0.67) | APEX1TDP1CA12CA2MEN1 | |
| SCHEMBL11779702 | 0.77 | APEX1 (0.61) | APEX1TDP1PGR | |
| SCHEMBL11665975 | 0.76 | APEX1 (0.60) | APEX1TDP1CA12CA2MEN1 | |
| SCHEMBL11664859 | 0.76 | APEX1 (0.60) | APEX1TDP1MEN1KMT2APGR | |
| SCHEMBL27978393 | 0.75 | TDP1 (0.66) | APEX1TDP1CA12CA2PGR | |
| SCHEMBL7168081 | 0.75 | APEX1 (0.59) | APEX1MEN1KMT2AAHRPTGS2 | |
| SCHEMBL20449124 | 0.75 | APEX1 (0.59) | APEX1TDP1CA2MEN1KMT2A | |
| SCHEMBL8600833 | 0.74 | TDP1 (0.80) | APEX1TDP1CA12CA2MEN1 | |
| SCHEMBL11623960 | 0.74 | APEX1 (0.57) | APEX1TDP1MEN1KMT2AALPL | |
| SCHEMBL11702251 | 0.73 | APEX1 (0.57) | APEX1TDP1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2003007955-A2 | BIPHENYL APURINIC/APYRIMIDINIC SITE ENDONUCLEASE INHIBITORS TO TREAT CANCER | CANCER RESEARCH TECHNOLOGY LIMITED (GB) | 2003-01-30 | — | — | WO | claimed |