Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.77 |
| ▸ | TRPC1 | P48995 | 2/20 | 0.60 |
| ▸ | TRPC3 | Q13507 | 2/20 | 0.60 |
| ▸ | STIM1 | Q13586 | 2/20 | 0.60 |
| ▸ | ORAI1 | Q96D31 | 2/20 | 0.60 |
| ▸ | STIM2 | Q9P246 | 2/20 | 0.60 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.48 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.48 |
| ▸ | PSEN1 | P49768 | 3/20 | 0.48 |
| ▸ | PSEN2 | P49810 | 3/20 | 0.48 |
| ▸ | APH1B | Q8WW43 | 3/20 | 0.48 |
| ▸ | NCSTN | Q92542 | 3/20 | 0.48 |
| ▸ | APH1A | Q96BI3 | 3/20 | 0.48 |
| ▸ | PSENEN | Q9NZ42 | 3/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.44 |
| ▸ | HPGD | P15428 | 5/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5539403 | 0.85 | MAPT (0.74) | MAPTTRPC1TRPC3STIM1ORAI1 | |
| SCHEMBL8345184 | 0.82 | TRPC1 (0.67) | MAPTTRPC1TRPC3STIM1ORAI1 | |
| SCHEMBL21419596 | 0.78 | TRPC1 (0.68) | MAPTTRPC1TRPC3STIM1ORAI1 | |
| SCHEMBL1194642 | 0.78 | TRPC1 (0.67) | MAPTTRPC1TRPC3STIM1ORAI1 | |
| SCHEMBL19692480 | 0.77 | TRPC1 (0.66) | MAPTTRPC1TRPC3STIM1ORAI1 | |
| SCHEMBL5533620 | 0.77 | TRPC1 (0.66) | MAPTTRPC1TRPC3STIM1ORAI1 | |
| SCHEMBL2325526 | 0.77 | MAPT (0.76) | MAPTTRPC1TRPC3STIM1ORAI1 | |
| SCHEMBL1814204 | 0.76 | ALDH1A1 (0.67) | MAPTTRPC1TRPC3STIM1ORAI1 | |
| SCHEMBL12931795 | 0.76 | TRPC1 (0.66) | MAPTTRPC1TRPC3STIM1ORAI1 | |
| SCHEMBL2722465 | 0.76 | TRPC1 (0.64) | MAPTTRPC1TRPC3STIM1ORAI1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2003007955-A2 | BIPHENYL APURINIC/APYRIMIDINIC SITE ENDONUCLEASE INHIBITORS TO TREAT CANCER | CANCER RESEARCH TECHNOLOGY LIMITED (GB) | 2003-01-30 | — | — | WO | claimed |