Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 11/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | LPAR1 | Q92633 | 2/20 | 0.34 |
| ▸ | BRD2 | P25440 | 3/20 | 0.33 |
| ▸ | BRD3 | Q15059 | 2/20 | 0.33 |
| ▸ | STAT3 | P40763 | 1/20 | 0.32 |
| ▸ | LPAR3 | Q9UBY5 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7194 | 1.00 | BRD4 (0.34) | BRD4SMN1; SMN2LMNARAB9AL3MBTL1 | |
| SCHEMBL7196 | 0.82 | SMN1; SMN2 (0.34) | BRD4SMN1; SMN2LMNARAB9AL3MBTL1 | |
| SCHEMBL6838 | 0.81 | L3MBTL1 (0.40) | BRD4SMN1; SMN2LMNARAB9AL3MBTL1 | |
| SCHEMBL13830791 | 0.80 | LPAR1 (0.39) | BRD4SMN1; SMN2LPAR1BRD2BRD3 | |
| SCHEMBL6830 | 0.79 | RAB9A (0.34) | BRD4SMN1; SMN2LMNARAB9AL3MBTL1 | |
| SCHEMBL2086 | 0.79 | LPAR1 (0.38) | SMN1; SMN2LMNARAB9AL3MBTL1LPAR1 | |
| SCHEMBL1924 | 0.79 | AR (0.38) | BRD4SMN1; SMN2LMNARAB9AL3MBTL1 | |
| SCHEMBL6942 | 0.79 | LPAR1 (0.38) | SMN1; SMN2LMNARAB9AL3MBTL1LPAR1 | |
| SCHEMBL1908 | 0.79 | AR (0.38) | BRD4SMN1; SMN2LMNARAB9AL3MBTL1 | |
| SCHEMBL6663 | 0.78 | ABCC3 (0.42) | LPAR1CYP2C9KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2483252-A2 | COMPOUNDS AS LYSOPHOSPHATIDIC ACID RECEPTOR ANTAGONISTS | Amira Pharmaceuticals, Inc. (US) | 2012-08-08 | — | — | EP | disclosed |
| WO-2011041694-A2 | COMPOUNDS AS LYSOPHOSPHATIDIC ACID RECEPTOR ANTAGONISTS | AMIRA PHARMACEUTICALS, INC. (US) | 2011-04-07 | — | — | WO | disclosed |