Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | RAB9A | P51151 | 2/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | LPAR1 | Q92633 | 4/20 | 0.34 |
| ▸ | BRD4 | O60885 | 7/20 | 0.32 |
| ▸ | LPAR3 | Q9UBY5 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | LPAR2 | Q9HBW0 | 1/20 | 0.32 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | BRD2 | P25440 | 3/20 | 0.31 |
| ▸ | BRD3 | Q15059 | 2/20 | 0.31 |
| ▸ | ABCC3 | O15438 | 1/20 | 0.31 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.31 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.31 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7195 | 0.82 | BRD4 (0.34) | SMN1; SMN2RAB9AL3MBTL1LMNALPAR1 | |
| SCHEMBL7194 | 0.82 | BRD4 (0.34) | SMN1; SMN2RAB9AL3MBTL1LMNALPAR1 | |
| SCHEMBL6830 | 0.81 | RAB9A (0.34) | SMN1; SMN2RAB9AL3MBTL1LMNALPAR1 | |
| SCHEMBL6734 | 0.76 | ADRB2 (0.38) | SMN1; SMN2RAB9AL3MBTL1LMNALPAR1 | |
| SCHEMBL1925 | 0.76 | LPAR1 (0.36) | SMN1; SMN2RAB9AL3MBTL1LMNALPAR1 | |
| SCHEMBL6943 | 0.76 | EPHX1 (0.35) | SMN1; SMN2RAB9AL3MBTL1LMNALPAR1 | |
| SCHEMBL1909 | 0.76 | LPAR1 (0.36) | SMN1; SMN2RAB9AL3MBTL1LMNALPAR1 | |
| SCHEMBL2087 | 0.76 | EPHX1 (0.35) | SMN1; SMN2RAB9AL3MBTL1LMNALPAR1 | |
| SCHEMBL1060 | 0.75 | LPAR1 (0.35) | SMN1; SMN2RAB9AL3MBTL1LMNALPAR1 | |
| SCHEMBL6836 | 0.75 | ALDH1A1 (0.38) | SMN1; SMN2RAB9AL3MBTL1LMNALPAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2483252-A2 | COMPOUNDS AS LYSOPHOSPHATIDIC ACID RECEPTOR ANTAGONISTS | Amira Pharmaceuticals, Inc. (US) | 2012-08-08 | — | — | EP | disclosed |
| WO-2011041694-A2 | COMPOUNDS AS LYSOPHOSPHATIDIC ACID RECEPTOR ANTAGONISTS | AMIRA PHARMACEUTICALS, INC. (US) | 2011-04-07 | — | — | WO | disclosed |