SCHEMBL7195686

SCHEMBL7195686

O=C1/C(=C\O)Cc2ccccc21

nearest known ligand 0.62

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MIF P14174 5/20 0.62
MAOA P21397 3/20 0.62
MAOB P27338 2/20 0.62
KDM4E B2RXH2 4/20 0.61
MEN1 O00255 1/20 0.61
KMT2A Q03164 1/20 0.61
CYP19A1 P11511 2/20 0.56
TNF P01375 2/20 0.56
STK17B O94768 1/20 0.55
BCHE P06276 1/20 0.55
CES1 P23141 1/20 0.55
ALDH1A1 P00352 4/20 0.54
MAPT P10636 3/20 0.54
POLB P06746 1/20 0.54
HPGD P15428 1/20 0.54
TYR P14679 1/20 0.54
CYP1A2 P05177 1/20 0.52
CYP2C19 P33261 1/20 0.52
GAA P10253 1/20 0.51
L3MBTL1 Q9Y468 1/20 0.51

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7195690 1.00 MIF (0.62) MIFMAOAMAOBKDM4EMEN1
SCHEMBL11428273 1.00 MIF (0.62) MIFMAOAMAOBKDM4EMEN1
SCHEMBL14821850 0.82 MAOB (0.64) MIFMAOBMEN1KMT2ACYP19A1
SCHEMBL10482650 0.82 MAOB (0.64) MIFMAOBMEN1KMT2ACYP19A1
Drinidene SCHEMBL121997 0.80 MAOA (0.65) MIFMAOAMAOBKDM4EMEN1
SCHEMBL25703544 0.80 KDM4E (0.66) MIFMAOAMAOBKDM4EMEN1
Drinidene SCHEMBL2188657 0.80 MAOA (0.65) MIFMAOAMAOBKDM4EMEN1
Drinidene SCHEMBL2188660 0.80 MAOA (0.65) MIFMAOAMAOBKDM4EMEN1
SCHEMBL2247155 0.79 MIF (0.62) MIFMAOAMAOBKDM4EMEN1
SCHEMBL2247150 0.79 MIF (0.62) MIFMAOAMAOBKDM4EMEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0668865-B1 INDENYL COMPOUNDS AND CATALYST COMPONENTS FOR THE POLYMERIZATION OF OLEFINS DSM NV (NL) 2003-07-23 EP disclosed
US-6130228-A Polycyclic compounds UNIVERSITY OF STRATHCLYDE (GB) 2000-10-10 US disclosed
US-5990253-A METALLOCENES HAVING THE INDENE RING BINDING AT THE 2-POSITION RATHER THAN AT THE 1-POSITION; COORDINATION CATALYSTS; LESS CRYSTALLIZATION IN THE ADDITION POLYMERIZATION OF ELASTOMERS DSM N.V. (NL) 1999-11-23 US disclosed
US-5646322-A Indenyl compounds and catalyst components for the polymerization of olefins DSM N.V. (NL) 1997-07-08 US disclosed
EP-0668865-A1 INDENYL COMPOUNDS AND CATALYST COMPONENTS FOR THE POLYMERIZATION OF OLEFINS DSM N.V. (NL) 1995-08-30 EP disclosed
WO-1994011406-A1 INDENYL COMPOUNDS AND CATALYST COMPONENTS FOR THE POLYMERIZATION OF OLEFINS DSM N.V. (NL) 1994-05-26 WO disclosed
US-4164514-A 2-Aminomethyleneindanone analgesic agents PFIZER INC. (US) 1979-08-14 US disclosed
US-4117012-A AMINES, QUATERNARY AMMONIUM COMPOUNDS, OLEFIN EPOXIDES, HYDROXYQUINOLINES, AMINE PHENOXIDES, GLYCIDYL HALIDES AND ETHERS PFIZER INC. (US) 1978-09-26 US disclosed
US-4064272-A 2-Aminomethyleneindanone analgesic agents PFIZER INC. (US) 1977-12-20 US disclosed
US-4022836-A 2-Aminomethyleneindanone analgesic agents PFIZER INC. (US) 1977-05-10 US disclosed