Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.33 |
| ▸ | BRD4 | O60885 | 1/20 | 0.32 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | KIF11 | P52732 | 2/20 | 0.31 |
| ▸ | DGAT1 | O75907 | 2/20 | 0.31 |
| ▸ | NR1H4 | Q96RI1 | 3/20 | 0.30 |
| ▸ | PTAFR | P25105 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3398271 | 0.94 | SMN1; SMN2 (0.31) | SMN1; SMN2NPC1LMNATP53RAB9A | |
| SCHEMBL3400108 | 0.91 | TSHR (0.32) | — | |
| SCHEMBL7037878 | 0.90 | NPC1 (0.33) | SMN1; SMN2NPC1LMNATP53RAB9A | |
| SCHEMBL3400017 | 0.90 | PTAFR (0.33) | SMN1; SMN2NPC1LMNATP53RAB9A | |
| SCHEMBL7198705 | 0.89 | RXRA (0.30) | KIF11 | |
| SCHEMBL3397219 | 0.88 | CNR1 (0.31) | — | |
| SCHEMBL7039419 | 0.88 | NPC1 (0.32) | SMN1; SMN2NPC1LMNATP53RAB9A | |
| SCHEMBL14448390 | 0.87 | — | — | |
| SCHEMBL3401848 | 0.86 | NR1H4 (0.31) | BRD4CREBBPNR1H4 | |
| SCHEMBL7035230 | 0.86 | NPC1 (0.32) | SMN1; SMN2NPC1LMNATP53RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6620953-B1 | Complexing dimethylbis(2-methyl-4,5-benzoindenyl)silane with transition metal compounds such as 2,4-di-tert-butylphenoxide, zirconium monochloride, to form polymerization catalysts | BASSELL POLYOLEFINE GMBH (DE) | 2003-09-16 | — | — | US | disclosed |