Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 7/20 | 0.51 |
| ▸ | PRKCA | P17252 | 4/20 | 0.51 |
| ▸ | LCK | P06239 | 2/20 | 0.49 |
| ▸ | IGF1R | P08069 | 2/20 | 0.49 |
| ▸ | GSK3A | P49840 | 2/20 | 0.49 |
| ▸ | CDK7 | P50613 | 2/20 | 0.49 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.49 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.49 |
| ▸ | JAK2 | O60674 | 1/20 | 0.49 |
| ▸ | BTK | Q06187 | 1/20 | 0.49 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.49 |
| ▸ | FLT3 | P36888 | 2/20 | 0.47 |
| ▸ | CDK9 | P50750 | 2/20 | 0.47 |
| ▸ | AURKA | O14965 | 1/20 | 0.47 |
| ▸ | PAK4 | O96013 | 1/20 | 0.47 |
| ▸ | ABL1 | P00519 | 1/20 | 0.47 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.47 |
| ▸ | FYN | P06241 | 1/20 | 0.47 |
| ▸ | CSF1R | P07333 | 1/20 | 0.47 |
| ▸ | RET | P07949 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7502631 | 0.84 | GSK3B (0.70) | GSK3BPRKCAKDR | |
| SCHEMBL8154461 | 0.80 | GSK3B (0.61) | GSK3BPRKCAFLT3CDK9PLK4 | |
| SCHEMBL7260690 | 0.79 | ADRB2 (0.49) | GSK3BPRKCALCKIGF1RGSK3A | |
| SCHEMBL7498380 | 0.79 | GSK3B (0.65) | GSK3BPRKCA | |
| SCHEMBL8161651 | 0.79 | GSK3B (0.80) | GSK3BPRKCAKDR | |
| SCHEMBL7502301 | 0.78 | GSK3B (0.80) | GSK3BPRKCAGSK3A | |
| SCHEMBL28374335 | 0.77 | GSK3B (0.48) | GSK3BPRKCA | |
| SCHEMBL7496292 | 0.75 | GSK3B (0.58) | GSK3BPRKCAKDR | |
| SCHEMBL7498955 | 0.75 | GSK3B (0.72) | GSK3BPRKCAGSK3A | |
| SCHEMBL7195024 | 0.74 | CCNT1 (0.76) | GSK3BPRKCAGSK3ACDK9PIM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6589977-B1 | Bisindolylpyrrole derivatives represented by general formula (I) which are useful in inhibiting cell death and expected as being useful as preventives and remedies for the progress of various diseases in the progress and worsening of which cell | SAGAMI CHEMICAL RESEARCH CENTER (JP) | 2003-07-08 | — | — | US | disclosed |
| EP-1152002-A1 | PYRROLE DERIVATIVES AND CELL DEATH INHIBITORS | SAGAMI CHEMICAL RESEARCH CENTER (JP) | 2001-11-07 | — | — | EP | disclosed |