Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB2 | P07550 | 1/20 | 0.49 |
| ▸ | PLK4 | O00444 | 1/20 | 0.47 |
| ▸ | NUAK1 | O60285 | 1/20 | 0.47 |
| ▸ | SRC | P12931 | 1/20 | 0.47 |
| ▸ | FLT4 | P35916 | 1/20 | 0.47 |
| ▸ | KDR | P35968 | 1/20 | 0.47 |
| ▸ | FLT3 | P36888 | 1/20 | 0.47 |
| ▸ | TEK | Q02763 | 1/20 | 0.47 |
| ▸ | HTR6 | P50406 | 1/20 | 0.47 |
| ▸ | GSK3B | P49841 | 6/20 | 0.46 |
| ▸ | JAK2 | O60674 | 1/20 | 0.46 |
| ▸ | LCK | P06239 | 1/20 | 0.46 |
| ▸ | IGF1R | P08069 | 1/20 | 0.46 |
| ▸ | GSK3A | P49840 | 1/20 | 0.46 |
| ▸ | CDK7 | P50613 | 1/20 | 0.46 |
| ▸ | BTK | Q06187 | 1/20 | 0.46 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.46 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.46 |
| ▸ | PRKCA | P17252 | 4/20 | 0.45 |
| ▸ | MTNR1A | P48039 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7260661 | 0.92 | ALDH1A1 (0.54) | ADRB2GSK3BPRKCABRD4ALDH1A1 | |
| SCHEMBL7261288 | 0.88 | ALDH1A1 (0.55) | PLK4NUAK1SRCFLT4KDR | |
| SCHEMBL7197086 | 0.79 | GSK3B (0.51) | ADRB2PLK4NUAK1SRCFLT4 | |
| SCHEMBL10616242 | 0.79 | ALDH1A1 (0.49) | ADRB2FLT3HTR6GSK3BJAK2 | |
| SCHEMBL11064105 | 0.78 | ADRB2 (0.58) | ADRB2HTR6GSK3BMTNR1AMTNR1B | |
| SCHEMBL7257625 | 0.76 | ALDH1A1 (0.55) | PLK4NUAK1SRCFLT4KDR | |
| SCHEMBL7502631 | 0.75 | GSK3B (0.70) | KDRGSK3BPRKCA | |
| SCHEMBL7257567 | 0.75 | EGFR (0.52) | PLK4NUAK1SRCFLT4KDR | |
| SCHEMBL7256796 | 0.75 | EGFR (0.71) | FLT3ALDH1A1KDM4EHPGDRAB9A | |
| SCHEMBL11399722 | 0.74 | ADRB2 (0.47) | ADRB2HTR6GSK3BMTNR1AMTNR1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6645983-B1 | Heterocyclic imines such as 3-(4-methoxyphenyl)-1,4-dihydro-4 -quinolinone, used as anticarcinogenic agents having cytolysis efficiency; side effect reduction | LABORATOIRE L. LAFON (FR) | 2003-11-11 | — | — | US | disclosed |
| EP-1202971-A2 | PHARMACEUTICAL COMPOSITIONS COMPRISING 4-QUINOLONES | LABORATOIRE L. LAFON (FR) | 2002-05-08 | — | — | EP | disclosed |
| WO-2002022074-A2 | USE OF 2- AND 4- QUINOLONES FOR INHIBITING INTIMAL NEO-PROLIFERATION | LABORATOIRE L. LAFON (FR) | 2002-03-21 | — | — | WO | disclosed |
| WO-2001012607-A2 | PHARMACEUTICAL COMPOSITIONS COMPRISING 4-QUINOLONES FOR TREATING CANCERS | LABORATOIRE L. LAFON (FR) | 2001-02-22 | — | — | WO | disclosed |