Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B2 | P37059 | 3/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | CCR9 | P51686 | 4/20 | 0.43 |
| ▸ | UQCRB | P14927 | 1/20 | 0.42 |
| ▸ | CA1 | P00915 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | EDNRA | P25101 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | CRHBP | P24387 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7815226 | 0.90 | EDNRA (0.50) | HSD17B2CCR9EDNRA | |
| SCHEMBL8659102 | 0.81 | EDNRA (0.49) | HSD17B2KDM4EALDH1A1RXFP1EDNRA | |
| SCHEMBL7198831 | 0.80 | EDNRA (0.49) | EDNRA | |
| SCHEMBL7198236 | 0.78 | EDNRA (0.56) | EDNRA | |
| SCHEMBL8802241 | 0.74 | EDNRA (0.52) | HSD17B2KDM4EALDH1A1EDNRAMEN1 | |
| SCHEMBL9493302 | 0.74 | EDNRA (0.51) | KDM4EALDH1A1CCR9EDNRA | |
| SCHEMBL7805397 | 0.73 | EDNRA (0.54) | EDNRA | |
| SCHEMBL10847225 | 0.72 | HSP90AA1 (0.43) | KDM4ECA1CA2RXFP1NPSR1 | |
| SCHEMBL8657212 | 0.71 | EDNRA (0.46) | KDM4ENPSR1EDNRA | |
| SCHEMBL4844072 | 0.71 | KDM4E (0.49) | KDM4EALDH1A1RXFP1NPSR1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6596719-B1 | Manufacturing those compounds, pharmaceutical compositions containing one or more of those compounds as endothelin antagonists, and a method of treating a subject having a disorder involving endothelin with the compounds of the | ACTELIO PHARMACEUTICALS LTD. (CH) | 2003-07-22 | — | — | US | disclosed |
| EP-1137642-A1 | BIS-SULFONAMIDES | Actelion Pharmaceuticals Ltd. (CH) | 2001-10-04 | — | — | EP | disclosed |
| WO-2001017976-A1 | BIS-SULFONAMIDES | ACTELION PHARMACEUTICALS LTD (CH) | 2001-03-15 | — | — | WO | disclosed |
| US-5750509-A | TREATMENT AGAINST INFECTIONS BY BACTERIA INCLUDING ENTEROCOCCUS, AND STAPHYLOCOCCUS | GRUPPO LEPETIT S.P.A. (IT) | 1998-05-12 | — | — | US | disclosed |
| EP-0596929-B1 | AMIDE DERIVATIVES OF ANTIBIOTIC A 40926 | LEPETIT SPA (IT) | 1995-07-26 | — | — | EP | disclosed |
| EP-0596929-A1 | AMIDE DERIVATIVES OF ANTIBIOTIC A 40926. | LEPETIT SPA (IT) | 1994-05-18 | — | — | EP | disclosed |
| WO-1993003060-A1 | AMIDE DERIVATIVES OF ANTIBIOTIC A 40926 | GRUPPO LEPETIT S.P.A. (IT) | 1993-02-18 | — | — | WO | disclosed |
| EP-0525499-A1 | Amide derivatives of antibiotic A 40926 | GRUPPO LEPETIT S.p.A. (IT) | 1993-02-03 | — | — | EP | disclosed |