Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRA | P25101 | 3/20 | 0.49 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.45 |
| ▸ | EDNRB | P24530 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | HMOX1 | P09601 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | CRHBP | P24387 | 1/20 | 0.41 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.41 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9493302 | 0.89 | EDNRA (0.51) | EDNRAEDNRBKDM4EALDH1A1 | |
| SCHEMBL8657212 | 0.85 | EDNRA (0.46) | EDNRAEDNRBKDM4E | |
| SCHEMBL7815226 | 0.82 | EDNRA (0.50) | EDNRAHSD17B2EDNRB | |
| SCHEMBL8656735 | 0.82 | EDNRA (0.70) | EDNRAEDNRB | |
| SCHEMBL8802241 | 0.81 | EDNRA (0.52) | EDNRAHSD17B2EDNRBMEN1KMT2A | |
| SCHEMBL7197121 | 0.81 | HSD17B2 (0.44) | EDNRAHSD17B2MEN1KMT2AKDM4E | |
| SCHEMBL6785011 | 0.79 | EDNRA (0.67) | EDNRAEDNRBMEN1KMT2AKDM4E | |
| SCHEMBL7293882 | 0.76 | EDNRA (0.72) | EDNRAEDNRB | |
| SCHEMBL8660654 | 0.72 | LMNA (0.58) | MEN1KMT2AKDM4ELMNAMAPT | |
| SCHEMBL9044409 | 0.72 | ALDH1A1 (0.55) | EDNRAEDNRBMEN1KMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5728706-A | ENDOTHELIN ANTAGONISTS | TANABE SEIYAKU CO., LTD. (JP) | 1998-03-17 | — | — | US | disclosed |
| EP-0658548-B1 | Benzenesulfonamide derivative and process for preparing thereof | TANABE SEIYAKU CO (JP) | 1997-11-19 | — | — | EP | disclosed |
| US-5589478-A | ENDOTHELIN ANTAGONISTS | TANABE SEIYAKU CO., LTD. (JP) | 1996-12-31 | — | — | US | disclosed |
| EP-0658548-A1 | Benzenesulfonamide derivative and process for preparing thereof | TANABE SEIYAKU CO., LTD. (JP) | 1995-06-21 | — | — | EP | disclosed |