Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | MTNR1A | P48039 | 6/20 | 0.38 |
| ▸ | MTNR1B | P49286 | 6/20 | 0.38 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.37 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.37 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.37 |
| ▸ | DHODH | Q02127 | 2/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7197433 | 0.94 | ALOX5 (0.40) | NPC1PKMRAB9AMTNR1AMTNR1B | |
| SCHEMBL7193945 | 0.93 | NPC1 (0.46) | NPC1PKMRAB9AMTNR1AMTNR1B | |
| SCHEMBL7189750 | 0.90 | ALOX5 (0.40) | NPC1PKMRAB9AMTNR1AMTNR1B | |
| SCHEMBL7188092 | 0.88 | PPARG (0.38) | NPC1PKMRAB9AMTNR1AMTNR1B | |
| SCHEMBL7194857 | 0.87 | NPC1 (0.44) | NPC1PKMRAB9AMTNR1AMTNR1B | |
| SCHEMBL7195769 | 0.86 | ALOX5 (0.38) | NPC1PKMRAB9AMTNR1AMTNR1B | |
| SCHEMBL7190577 | 0.86 | TAS1R3 (0.43) | NPC1RAB9AMTNR1AMTNR1BALOX5 | |
| SCHEMBL7194985 | 0.85 | NPC1 (0.40) | NPC1PKMRAB9AALOX5TAS1R3 | |
| SCHEMBL7197432 | 0.84 | NPC1 (0.44) | NPC1PKMRAB9AALOX5 | |
| SCHEMBL7189707 | 0.84 | ALOX5 (0.43) | NPC1PKMRAB9AMTNR1AMTNR1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20030065039-A1 | Biologically active 1,3-bis-aromatic-prop-2-en-1-ones, 1,3-bis-aromatic-propan-1-ones, and 1,3-bis-aromatic-prop-2-yn-1-ones | STATENS SERUM INSTITUTE (DK) | 2003-04-03 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030065039-A1 | Biologically active 1,3-bis-aromatic-prop-2-en-1-ones, 1,3-bis-aromatic-propan-1-ones, and 1,3-bis-aromatic-prop-2-yn-1-ones | AKR1C3, AKR1C1, AKR1A1 | NPC1 3105/4885PKM 749/4885RAB9A 3774/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.