Tetrahydrofuran

Tetrahydrofuran

SCHEMBL7197722

C1CCOC1.c1ccc([B-](c2ccccc2)(c2ccccc2)c2ccccc2)cc1

nearest known ligand 0.40

Full drug profile on Sugi Atlas →

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 3/20 0.40
LMNA P02545 3/20 0.38
CRHBP P24387 2/20 0.37
CRHR2 Q13324 2/20 0.37
SMN1; SMN2 Q16637 2/20 0.37
HTT P42858 2/20 0.37
FAAH O00519 1/20 0.33
MGLL Q99685 1/20 0.33
NCOA3 Q9Y6Q9 1/20 0.33
AR P10275 1/20 0.33
KMT2A Q03164 3/20 0.32
MEN1 O00255 1/20 0.32
POLB P06746 1/20 0.32
GAA P10253 1/20 0.32
FKBP1A P62942 1/20 0.32
MAPT P10636 1/20 0.32
CFTR P13569 1/20 0.31
GOPC Q9HD26 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Biphenyl SCHEMBL27994032 0.81 ALDH1A1 (0.53) ALDH1A1LMNACRHBPCRHR2SMN1; SMN2
Biphenyl SCHEMBL2642362 0.81 ALDH1A1 (0.53) ALDH1A1LMNACRHBPCRHR2SMN1; SMN2
Morpholine SCHEMBL11760744 0.79 MEN1 (0.46) ALDH1A1LMNACRHBPCRHR2SMN1; SMN2
Morpholine SCHEMBL9784163 0.79 LMNA (0.34) LMNACRHBPCRHR2SMN1; SMN2HTT
Biphenyl SCHEMBL27496289 0.79 ALDH1A1 (0.50) ALDH1A1LMNACRHBPCRHR2SMN1; SMN2
Fluoride SCHEMBL699471 0.78 ALDH1A1 (0.44) ALDH1A1LMNASMN1; SMN2HTTMGLL
Fluoride SCHEMBL700882 0.78 ALDH1A1 (0.44) ALDH1A1LMNASMN1; SMN2HTTMGLL
Benzene SCHEMBL31091106 0.78 ALDH1A1 (0.50) ALDH1A1LMNASMN1; SMN2HTTMGLL
SCHEMBL11707018 0.78 ALDH1A1 (0.50) ALDH1A1LMNASMN1; SMN2HTTMGLL
SCHEMBL143876 0.78 ALDH1A1 (0.50) ALDH1A1LMNASMN1; SMN2HTTMGLL

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0974601-B1 Olefin polymerization catalyst and process for producing olefin polymer JAPAN POLYCHEM CORP (JP) 2003-09-10 EP disclosed
US-6444763-B1 Polymerization of olefins MITSUBISHI CHEMICAL CORPORATION (JP) 2002-09-03 US disclosed
EP-0874006-B1 Phyllosilicate-supported catalyst for the polymerisation of olefins MITSUBISHI CHEM CORP (JP) 2001-08-08 EP disclosed
WO-2000069959-A2 POLYMER LAYERED INORGANIC NANOCOMPOSITES NATIONAL INSTITUTE OF STANDARDS & TECHNOLOGY (US) 2000-11-23 WO disclosed
US-6048817-A Polymerization of olefins MITSUBISHI CHEMICAL CORPORATION (JP) 2000-04-11 US disclosed
EP-0974601-A2 Olefin polymerization catalyst and process for producing olefin polymer Japan Polychem Corporation (JP) 2000-01-26 EP disclosed