Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR84 | Q9NQS5 | 5/20 | 0.43 |
| ▸ | HCAR2 | Q8TDS4 | 4/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | PARP1 | P09874 | 1/20 | 0.42 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.41 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.41 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9705822 | 0.96 | PARP1 (0.46) | HCAR2POLBPARP1ADORA3ADORA2A | |
| SCHEMBL246326 | 0.82 | PDE5A (0.53) | HCAR2POLB | |
| SCHEMBL1586540 | 0.78 | PARP1 (0.55) | GPR84POLBPARP1 | |
| SCHEMBL8326986 | 0.78 | NOS1 (0.54) | HCAR2POLB | |
| SCHEMBL26136040 | 0.78 | ADORA3 (0.41) | GPR84PARP1ADORA3ADORA2AADORA1 | |
| SCHEMBL7197836 | 0.78 | PARP1 (0.58) | GPR84HCAR2POLBPARP1 | |
| SCHEMBL8169941 | 0.75 | POLB (0.46) | GPR84POLBPARP1 | |
| SCHEMBL9706231 | 0.74 | PARP1 (0.54) | HCAR2PARP1 | |
| SCHEMBL8501957 | 0.74 | PARP1 (0.60) | POLBPARP1 | |
| SCHEMBL3857628 | 0.74 | POLB (0.47) | GPR84POLBPARP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6534511-B1 | The use of certain 6-arylpyrazolo(3,4-d)pyrimidin-4-ones, 2 arylquinazolin-4-ones, 2-arylpurin-6-ones and 2-arylpyrido(3,2- d)pyrimidin-4-ones, or a pharmaceutically acceptable salt thereof, forsexual disorders | PFIZER INC. | 2003-03-18 | — | — | US | disclosed |
| EP-0793498-B1 | BICYCLIC HETEROCYCLIC COMPOUNDS FOR THE TREATMENT OF IMPOTENCE | PFIZER LTD (GB) | 2002-12-11 | — | — | EP | disclosed |
| US-6225315-B1 | ADMINISTERING A CGMP PDE INHIBITOR. | PFIZER INC | 2001-05-01 | — | — | US | disclosed |
| EP-1022026-A2 | Pharmaceutical compositions for treating nitrate-induced tolerance | Pfizer Limited (GB) | 2000-07-26 | — | — | EP | disclosed |
| EP-0793498-A1 | BICYCLIC HETEROCYCLIC COMPOUNDS FOR THE TREATMENT OF IMPOTENCE | Pfizer Limited (GB) | 1997-09-10 | — | — | EP | disclosed |
| WO-1996016657-A1 | BICYCLIC HETEROCYCLIC COMPOUNDS FOR THE TREATMENT OF IMPOTENCE | PFIZER LIMITED (GB) | 1996-06-06 | — | — | WO | disclosed |