SCHEMBL7197964

SCHEMBL7197964

C[Si](C)(C)Oc1cc[c]c2cc3cc4ccccc4cc3cc12

nearest known ligand 0.36

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
NQO1 P15559 1/20 0.36
ELANE P08246 1/20 0.33
MAPT P10636 1/20 0.31
ALDH1A1 P00352 1/20 0.30
HPGD P15428 1/20 0.30
SMN1; SMN2 Q16637 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7205849 0.86 CA12 (0.33) NQO1
SCHEMBL2252041 0.79 NQO1 (0.60) NQO1MAPTALDH1A1HPGDSMN1; SMN2
SCHEMBL7196063 0.77
SCHEMBL1557069 0.75 CYP1A2 (0.39) NQO1ELANEMAPTALDH1A1HPGD
SCHEMBL2251995 0.75 TLR8 (0.40) NQO1ALDH1A1SMN1; SMN2
SCHEMBL2253900 0.72 CNR1 (0.45) MAPT
SCHEMBL69340 0.71 CYP2A6 (0.41) NQO1ELANEMAPTALDH1A1HPGD
SCHEMBL510183 0.68 ALDH1A1 (0.42) MAPTALDH1A1HPGD
SCHEMBL510351 0.68 ALDH1A1 (0.42) MAPTALDH1A1HPGD
SCHEMBL9233742 0.68 NQO1 (0.44) NQO1ELANEMAPTALDH1A1HPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6509426-B2 Dichloro(1,1'-dimethylsilylenebis(2-methyl-4-(4-methoxyphenyl) -4H-azulenyl))zirconium, for example; can produce polyolefin with high molecular weight and high melting point for extrusion or injection moldability JAPAN POLYCHEM CORPORATION (JP) 2003-01-21 US claimed
US-6509426-B2 Dichloro(1,1'-dimethylsilylenebis(2-methyl-4-(4-methoxyphenyl) -4H-azulenyl))zirconium, for example; can produce polyolefin with high molecular weight and high melting point for extrusion or injection moldability JAPAN POLYCHEM CORPORATION (JP) 2003-01-21 US disclosed
US-20010023296-A1 Novel transition metal compound, catalyst component for olefin polymerization and process for the preparation of alpha-olefin polymer JAPAN POLYCHEM CORPORATION (JP) 2001-09-20 US disclosed
US-6218558-B1 BRIDGED OXYGEN-, NITROGEN- OR SULFUR-CONTAINING METALLOCENE CATALYST CONTAINING AT LEAST CYCLOPENTADIENE RING FUSED TO A C7-10 RING JAPAN POLYCHEM CORPORATION (JP) 2001-04-17 US disclosed
EP-0963996-A2 Novel transition metal compound, catalyst component for olefin polymerization and process for the preparation of alpha-olefin polymer Japan Polychem Corporation (JP) 1999-12-15 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20010023296-A1 Novel transition metal compound, catalyst component for olefin polymerization and process for the preparation of alpha-olefin polymer OSTC, TCP1, COG1 NQO1 309/4885ELANE 3255/4885MAPT 1187/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.