Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.39 |
| ▸ | PKM | P14618 | 3/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 3/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 3/20 | 0.33 |
| ▸ | ABL1 | P00519 | 2/20 | 0.33 |
| ▸ | CGAS | Q8N884 | 1/20 | 0.33 |
| ▸ | GLA | P06280 | 1/20 | 0.33 |
| ▸ | NQO2 | P16083 | 4/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | F2 | P00734 | 1/20 | 0.32 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.32 |
| ▸ | JAK2 | O60674 | 1/20 | 0.32 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.32 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL719555 | 0.82 | NPSR1 (0.48) | NPSR1KDM4EALDH1A1PKMSMN1; SMN2 | |
| SCHEMBL29352298 | 0.82 | NPSR1 (0.48) | NPSR1KDM4EALDH1A1PKMSMN1; SMN2 | |
| SCHEMBL29556424 | 0.82 | NPSR1 (0.48) | NPSR1KDM4EALDH1A1PKMSMN1; SMN2 | |
| SCHEMBL118992 | 0.82 | NPSR1 (0.48) | NPSR1KDM4EALDH1A1PKMSMN1; SMN2 | |
| SCHEMBL13256088 | 0.81 | NPSR1 (0.47) | NPSR1KDM4EALDH1A1PKMSMN1; SMN2 | |
| SCHEMBL10255541 | 0.81 | NPSR1 (0.47) | NPSR1KDM4EALDH1A1PKMSMN1; SMN2 | |
| SCHEMBL12338199 | 0.81 | NPSR1 (0.47) | NPSR1KDM4EALDH1A1PKMSMN1; SMN2 | |
| SCHEMBL3792082 | 0.81 | NPSR1 (0.47) | NPSR1KDM4EALDH1A1PKMSMN1; SMN2 | |
| SCHEMBL19627710 | 0.81 | NPSR1 (0.47) | NPSR1KDM4EALDH1A1PKMSMN1; SMN2 | |
| SCHEMBL1397019 | 0.79 | NPSR1 (0.45) | NPSR1KDM4EALDH1A1PKMSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 58 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12281118-B2 | Nitrogen-containing fused heterocyclic SHP2 inhibitor compound, preparation method, and use | SHANGHAI RINGENE BIOPHARMA CO., LTD. (CN) | 2025-04-22 | — | — | US | disclosed |
| CN-114751903-B | Nitrogen-containing fused heterocycle SHP2 inhibitor compound, preparation method and application | 上海凌达生物医药有限公司 | 2023-09-15 | — | — | CN | disclosed |
| CN-114751903-A | Nitrogen-containing fused heterocyclic SHP2 inhibitor compound, preparation method and application | 上海凌达生物医药有限公司 | 2022-07-15 | — | — | CN | disclosed |
| US-20220127271-A1 | NITROGEN-CONTAINING FUSED HETEROCYCLIC SHP2 INHIBITOR COMPOUND, PREPARATION METHOD, AND USE | SHANGHAI RINGENE BIOPHARMA CO., LTD. (CN) | 2022-04-28 | — | — | US | disclosed |
| US-20220127271-A1 | NITROGEN-CONTAINING FUSED HETEROCYCLIC SHP2 INHIBITOR COMPOUND, PREPARATION METHOD, AND USE | SHANGHAI RINGENE BIOPHARMA CO., LTD. (CN) | 2022-04-28 | — | — | US | disclosed |
| CN-114269746-A | Spiro aromatic ring compound, preparation and application thereof | 上海奕拓医药科技有限责任公司 | 2022-04-01 | — | — | CN | disclosed |
| CN-111153901-B | Nitrogen-containing fused heterocyclic SHP2 inhibitor compound, preparation method and application | 上海凌达生物医药有限公司 | 2022-01-25 | — | — | CN | disclosed |
| EP-3878853-A1 | NITROGEN-CONTAINING FUSED HETEROCYCLIC SHP2 INHIBITOR COMPOUND, PREPARATION METHOD, AND USE | Shanghai Ringene BioPharma Co., Ltd. (CN) | 2021-09-15 | — | — | EP | disclosed |
| EP-3878853-A1 | NITROGEN-CONTAINING FUSED HETEROCYCLIC SHP2 INHIBITOR COMPOUND, PREPARATION METHOD, AND USE | Shanghai Ringene BioPharma Co., Ltd. (CN) | 2021-09-15 | — | — | EP | disclosed |
| WO-2021018287-A1 | SPIROAROMATIC COMPOUND, PREPARATION AND APPLICATION THEREOF | 上海奕拓医药科技有限责任公司 | 2021-02-04 | — | — | WO | disclosed |
| US-7786044-B2 | e.g.4-Amino-6-(4-chlorophenyl)-5-fluoro-3-vinylpyridine-2-carboxylic acid; 4-Acetylamino-6-(4-chloro-2-fluoro-3-methoxyphenyl)-3-trimethylsilanylethynylpyridine-2-carboxylic acid methyl ester; | DOW AGROSCIENCES LLC (US) | 2010-08-31 | — | — | US | disclosed |
| WO-2010092339-A1 | PYRIMIDINE DERIVATIVES AND THEIR USE AS HERBICIDES | SYNGENTA LIMITED (GB) | 2010-08-19 | — | — | WO | disclosed |
| WO-2010092339-A1 | PYRIMIDINE DERIVATIVES AND THEIR USE AS HERBICIDES | SYNGENTA LIMITED (GB) | 2010-08-19 | — | — | WO | disclosed |
| US-20100041556-A1 | 2-SUBSTITUTED-6-AMINO-5-ALKYL, ALKENYL OR ALKYNYL-4-PYRIMIDINECARBOXYLIC ACIDS AND 6-SUBSTITUTED-4-AMINO-3-ALKYL, ALKENYL OR ALKYNYL PICOLINIC ACIDS AND THEIR USE AS HERBICIDES | DOW AGROSCIENCES LLC (US) | 2010-02-18 | — | — | US | disclosed |
| US-20100041556-A1 | 2-SUBSTITUTED-6-AMINO-5-ALKYL, ALKENYL OR ALKYNYL-4-PYRIMIDINECARBOXYLIC ACIDS AND 6-SUBSTITUTED-4-AMINO-3-ALKYL, ALKENYL OR ALKYNYL PICOLINIC ACIDS AND THEIR USE AS HERBICIDES | DOW AGROSCIENCES LLC (US) | 2010-02-18 | — | — | US | disclosed |
| US-20100041556-A1 | 2-SUBSTITUTED-6-AMINO-5-ALKYL, ALKENYL OR ALKYNYL-4-PYRIMIDINECARBOXYLIC ACIDS AND 6-SUBSTITUTED-4-AMINO-3-ALKYL, ALKENYL OR ALKYNYL PICOLINIC ACIDS AND THEIR USE AS HERBICIDES | DOW AGROSCIENCES LLC (US) | 2010-02-18 | — | — | US | disclosed |
| WO-2009046090-A1 | 2-SUBSTITUTED-6-AMINO-5-ALKYL, ALKENYL OR ALKYNYL-4-PYRIMIDINECARBOXYLIC ACIDS AND 6-SUBSTITUTED-4-AMINO-3- ALKYL, ALKENYL OR ALKYNYL PICOLINIC ACIDS AND THEIR USE AS HERBICIDES | DOW AGROSCIENCES LLC (US) | 2009-04-09 | — | — | WO | disclosed |
| US-20090088322-A1 | 2-SUBSTITUTED-6-AMINO-5-ALKYL, ALKENYL OR ALKYNYL-4-PYRIMIDINECARBOXYLIC ACIDS AND 6-SUBSTITUTED-4-AMINO-3- ALKYL, ALKENYL OR ALKYNYL PICOLINIC ACIDS AND THEIR USE AS HERBICIDES | DOW AGROSCIENCES LLC (US) | 2009-04-02 | — | — | US | disclosed |
| US-20090088322-A1 | 2-SUBSTITUTED-6-AMINO-5-ALKYL, ALKENYL OR ALKYNYL-4-PYRIMIDINECARBOXYLIC ACIDS AND 6-SUBSTITUTED-4-AMINO-3- ALKYL, ALKENYL OR ALKYNYL PICOLINIC ACIDS AND THEIR USE AS HERBICIDES | DOW AGROSCIENCES LLC (US) | 2009-04-02 | — | — | US | disclosed |
| US-20090088322-A1 | 2-SUBSTITUTED-6-AMINO-5-ALKYL, ALKENYL OR ALKYNYL-4-PYRIMIDINECARBOXYLIC ACIDS AND 6-SUBSTITUTED-4-AMINO-3- ALKYL, ALKENYL OR ALKYNYL PICOLINIC ACIDS AND THEIR USE AS HERBICIDES | DOW AGROSCIENCES LLC (US) | 2009-04-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12281118-B2 | Nitrogen-containing fused heterocyclic SHP2 inhibitor compound, preparation method, and use | PTPN1, PTPN7, PTPN9 | NPSR1 1693/4885KDM4E 932/4885ALDH1A1 3157/4885 |
| US-20100041556-A1 | 2-SUBSTITUTED-6-AMINO-5-ALKYL, ALKENYL OR ALKYNYL-4-PYRIMIDINECARBOXYLIC ACIDS AND 6-SUBSTITUTED-4-AMINO-3-ALKYL, ALKENYL OR ALKYNYL PICOLINIC ACIDS AND THEIR USE AS HERBICIDES | AADAC, AASDHPPT, AADAT | NPSR1 1621/4885KDM4E 608/4885ALDH1A1 1070/4885 |
| US-20090088322-A1 | 2-SUBSTITUTED-6-AMINO-5-ALKYL, ALKENYL OR ALKYNYL-4-PYRIMIDINECARBOXYLIC ACIDS AND 6-SUBSTITUTED-4-AMINO-3- ALKYL, ALKENYL OR ALKYNYL PICOLINIC ACIDS AND THEIR USE AS HERBICIDES | AADAC, AASDHPPT, AADAT | NPSR1 1621/4885KDM4E 608/4885ALDH1A1 1070/4885 |
| US-20220127271-A1 | NITROGEN-CONTAINING FUSED HETEROCYCLIC SHP2 INHIBITOR COMPOUND, PREPARATION METHOD, AND USE | PTPN1, PTPN7, PTPN9 | NPSR1 1693/4885KDM4E 932/4885ALDH1A1 3157/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.