Sugi Predict

Sugi Predict / Compounds / SCHEMBL118992

SCHEMBL118992

SCHEMBL118992

COC(=O)c1nc(Cl)nc(N)c1Cl

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ NPSR1 Q6W5P4 1/20 0.48
▸ KDM4E B2RXH2 5/20 0.41
▸ ALDH1A1 P00352 5/20 0.41
▸ PKM P14618 3/20 0.41
▸ SMN1; SMN2 Q16637 3/20 0.41
▸ L3MBTL1 Q9Y468 3/20 0.41
▸ RCE1 Q9Y256 1/20 0.38
▸ HPGD P15428 2/20 0.36
▸ HSD17B10 Q99714 1/20 0.36
▸ NQO2 P16083 5/20 0.36
▸ TDP1 Q9NUW8 1/20 0.35
▸ GAA P10253 3/20 0.35
▸ ABL1 P00519 2/20 0.35
▸ GLA P06280 1/20 0.35
▸ MAPT P10636 2/20 0.35
▸ ATM Q13315 2/20 0.35
▸ LMNA P02545 1/20 0.35
▸ CYP1A2 P05177 1/20 0.34
▸ F2 P00734 1/20 0.33
▸ DAPK3 O43293 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29556424 1.00 NPSR1 (0.48) NPSR1KDM4EALDH1A1PKMSMN1; SMN2
SCHEMBL10087227 0.84 NPSR1 (0.47) NPSR1KDM4EALDH1A1PKMSMN1; SMN2
SCHEMBL13256088 0.84 NPSR1 (0.47) NPSR1KDM4EALDH1A1PKMSMN1; SMN2
SCHEMBL19627710 0.84 NPSR1 (0.47) NPSR1KDM4EALDH1A1PKMSMN1; SMN2
SCHEMBL117827 0.82 NPSR1 (0.54) NPSR1KDM4EALDH1A1PKMSMN1; SMN2
SCHEMBL29502585 0.82 NPSR1 (0.54) NPSR1KDM4EALDH1A1PKMSMN1; SMN2
SCHEMBL14662346 0.82 NPSR1 (0.45) NPSR1KDM4EALDH1A1PKMSMN1; SMN2
SCHEMBL719803 0.82 NPSR1 (0.45) NPSR1KDM4EALDH1A1PKMSMN1; SMN2
SCHEMBL1397019 0.82 NPSR1 (0.45) NPSR1KDM4EALDH1A1PKMSMN1; SMN2
SCHEMBL109063 0.81 NPSR1 (0.48) NPSR1KDM4EALDH1A1PKMSMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 152 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3458442-B1 SYNTHESIS OF 6-ARYL-4-AMINOPICOLINATES AND 2-ARYL-6-AMINOPYRIMIDINE-4-CARBOXYLATES BY DIRECT SUZUKI COUPLING CORTEVA AGRISCIENCE LLC (US) 2022-12-28 — — EP claimed
US-10570114-B2 Synthesis of 6-aryl-4-aminopicolinates and 2-aryl-6-aminopyrimidine-4-carboxylates by direct suzuki coupling DOW AGROSCIENCES LLC (US) 2020-02-25 — — US claimed
EP-3458442-A1 SYNTHESIS OF 6-ARYL-4-AMINOPICOLINATES AND 2-ARYL-6-AMINOPYRIMIDINE-4-CARBOXYLATES BY DIRECT SUZUKI COUPLING Dow Agrosciences LLC (US) 2019-03-27 — — EP claimed
US-20180334445-A1 SYNTHESIS OF 6-ARYL-4-AMINOPICOLINATES AND 2-ARYL-6-AMINOPYRIMIDINE-4-CARBOXYLATES BY DIRECT SUZUKI COUPLING DOW AGROSCIENCES LLC (US) 2018-11-22 — — US claimed
WO-2017201377-A1 SYNTHESIS OF 6-ARYL-4-AMINOPICOLINATES AND 2-ARYL-6-AMINOPYRIMIDINE-4-CARBOXYLATES BY DIRECT SUZUKI COUPLING DOW AGROSCIENCES LLC (US) 2017-11-23 — — WO claimed
US-20170334878-A1 SYNTHESIS OF 6-ARYL-4-AMINOPICOLINATES AND 2-ARYL-6-AMINOPYRIMIDINE-4-CARBOXYLATES BY DIRECT SUZUKI COUPLING DOW AGROSCIENCES LLC (US) 2017-11-23 — — US claimed
EP-2970185-B1 4-AMINO-6-(HETEROCYCLIC)PICOLINATES AND 6-AMINO-2-(HETEROCYCLIC)PYRIMIDINE-4-CARBOXYLATES AND THEIR USE AS HERBICIDES CORTEVA AGRISCIENCE LLC (US) 2023-07-12 — — EP disclosed
EP-2970185-B1 4-AMINO-6-(HETEROCYCLIC)PICOLINATES AND 6-AMINO-2-(HETEROCYCLIC)PYRIMIDINE-4-CARBOXYLATES AND THEIR USE AS HERBICIDES CORTEVA AGRISCIENCE LLC (US) 2023-07-12 — — EP disclosed
EP-3458442-B1 SYNTHESIS OF 6-ARYL-4-AMINOPICOLINATES AND 2-ARYL-6-AMINOPYRIMIDINE-4-CARBOXYLATES BY DIRECT SUZUKI COUPLING CORTEVA AGRISCIENCE LLC (US) 2022-12-28 — — EP disclosed
CN-114478507-A Pyrimidine oxazole compound and application thereof 东莞市东阳光农药研发有限公司 2022-05-13 — — CN disclosed
CN-108689924-B 4-amino-6- (4-substituted phenyl) -pyridine-2-carboxylic acid esters and their use as herbicides 美国陶氏益农公司 2022-04-12 — — CN disclosed
CN-113292502-A Novel 4-aminopyridine and 6-aminopyrimidine carboxylates as herbicides 美国陶氏益农公司 2021-08-24 — — CN disclosed
EP-3479696-B1 PYRIDINE-BASED COMPOUND INCLUDING ISOXAZOLINE RING, AND USE THEREOF AS HERBICIDE MOGHU RES CENTER LTD (KR) 2021-06-09 — — EP disclosed
US-20090048109-A1 2-(2-FLUORO-SUBSTITUTED PHENYL)-6-AMINO-5-CHLORO-4-PYRIMIDINECARBOXYLATES AND THEIR USE AS HERBICIDES DOW AGROSCIENCES LLC (US) 2009-02-19 — — US disclosed
WO-2009023438-A1 2-(2-FLUORO-SUBSTITUTED PHENYL)-6-AMINO-5-CHLORO-4-PYRIMIDINECARBOXYLATES AND THEIR USE AS HERBICIDES DOW AGROSCIENCES LLC (US) 2009-02-19 — — WO disclosed
EP-1971579-A1 2-(POLY-SUBSTITUTED ARYL)-6-AMINO-5-HALO-4-PYRIMIDINECARBOXYLIC ACIDS AND THEIR USE AS HERBICIDES Dow AgroSciences LLC (US) 2008-09-24 — — EP disclosed
US-20080091016-A1 2-(Poly-substituted aryl)-6-amino-5-halo-4-pyrimidinecarboxylic acids and their use as herbicides DOW AGROSCIENCES LLC (US) 2008-04-17 — — US disclosed
US-7300907-B2 2-(Poly-substituted aryl)-6-amino-5-halo-4-pyrimidinecarboxylic acids and their use as herbicides DOW AGROSCIENCES LLC (US) 2007-11-27 — — US disclosed
US-20070179059-A1 2-(Poly-substituted aryl)-6-amino-5-halo-4-pyrimidinecarboxylic acids and their use as herbicides CORTEVA AGRISCIENCE LLC 2007-08-02 — — US disclosed
WO-2007082076-A1 2-(POLY-SUBSTITUTED ARYL)-6-AMINO-5-HALO-4-PYRIMIDINECARBOXYLIC ACIDS AND THEIR USE AS HERBICIDES DOW AGROSCIENCES LLC (US) 2007-07-19 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10570114-B2 Synthesis of 6-aryl-4-aminopicolinates and 2-aryl-6-aminopyrimidine-4-carboxylates by direct suzuki coupling DDC, AAAS, AASDHPPT NPSR1 4740/4885KDM4E 12/4885ALDH1A1 1466/4885
US-20090048109-A1 2-(2-FLUORO-SUBSTITUTED PHENYL)-6-AMINO-5-CHLORO-4-PYRIMIDINECARBOXYLATES AND THEIR USE AS HERBICIDES DDT, DDC, PFAS NPSR1 3407/4885KDM4E 465/4885ALDH1A1 348/4885
US-20080091016-A1 2-(Poly-substituted aryl)-6-amino-5-halo-4-pyrimidinecarboxylic acids and their use as herbicides DDT, DDC, HDHD5 NPSR1 1155/4885KDM4E 567/4885ALDH1A1 839/4885
US-20170334878-A1 SYNTHESIS OF 6-ARYL-4-AMINOPICOLINATES AND 2-ARYL-6-AMINOPYRIMIDINE-4-CARBOXYLATES BY DIRECT SUZUKI COUPLING DDC, AAAS, AASDHPPT NPSR1 4718/4885KDM4E 13/4885ALDH1A1 1269/4885
US-20180334445-A1 SYNTHESIS OF 6-ARYL-4-AMINOPICOLINATES AND 2-ARYL-6-AMINOPYRIMIDINE-4-CARBOXYLATES BY DIRECT SUZUKI COUPLING DDC, AAAS, AASDHPPT NPSR1 4740/4885KDM4E 12/4885ALDH1A1 1466/4885
US-20070179059-A1 2-(Poly-substituted aryl)-6-amino-5-halo-4-pyrimidinecarboxylic acids and their use as herbicides DDT, DDC, HDHD5 NPSR1 1155/4885KDM4E 567/4885ALDH1A1 839/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.