Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.63 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.50 |
| ▸ | MEN1 | O00255 | 3/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | TSHR | P16473 | 2/20 | 0.49 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.49 |
| ▸ | CHRM5 | P08912 | 2/20 | 0.49 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.49 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.49 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.49 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2539077 | 0.90 | ITGB3 (0.52) | SIGMAR1KDM4EALDH1A1MEN1KMT2A | |
| SCHEMBL4041964 | 0.85 | KDM4E (0.59) | SIGMAR1KDM4EALDH1A1MEN1KMT2A | |
| SCHEMBL18789009 | 0.84 | SIGMAR1 (0.48) | SIGMAR1KDM4EALDH1A1MEN1KMT2A | |
| SCHEMBL11006978 | 0.83 | SIGMAR1 (0.61) | SIGMAR1KDM4EALDH1A1MEN1KMT2A | |
| Hydrochloric Acid SCHEMBL6623121 | 0.83 | KDM4E (0.57) | SIGMAR1KDM4EALDH1A1MEN1KMT2A | |
| SCHEMBL3692903 | 0.83 | SIGMAR1 (0.61) | SIGMAR1KDM4EALDH1A1MEN1KMT2A | |
| SCHEMBL7826195 | 0.83 | KDM4E (0.57) | SIGMAR1KDM4EALDH1A1MEN1KMT2A | |
| Hydrochloric Acid SCHEMBL27487445 | 0.83 | KDM4E (0.57) | SIGMAR1KDM4EALDH1A1MEN1KMT2A | |
| SCHEMBL5173732 | 0.82 | KDM4E (0.56) | SIGMAR1KDM4EALDH1A1MEN1KMT2A | |
| Potassium Ion SCHEMBL6299871 | 0.81 | SIGMAR1 (0.59) | SIGMAR1KDM4EALDH1A1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6596724-B2 | Used in promoting weight loss and treating eating disorders | BRISTOL-MYERS SQUIBB COMPANY | 2003-07-22 | — | — | US | disclosed |
| US-20020013323-A1 | Oxadiazole and thiadiazole derivatives of dihydropyridine NPY antagonists | BRISTOL-MYERS SQUIBB COMPANY | 2002-01-31 | — | — | US | disclosed |
| WO-1997007117-A1 | 2-ACYLAMINOPROPANAMINES AS GROWTH HORMONE SECRETAGOGUES | ELI LILLY AND COMPANY (US) | 1997-02-27 | — | — | WO | disclosed |
| WO-1996041633-A1 | METHODS OF TREATING COLD AND ALLERGIC RHINITIS | ELI LILLY AND COMPANY (US) | 1996-12-27 | — | — | WO | disclosed |
| WO-1996029074-A1 | METHODS OF TREATING OR PREVENTING PAIN OR NOCICEPTION | ELI LILLY AND COMPANY (US) | 1996-09-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020013323-A1 | Oxadiazole and thiadiazole derivatives of dihydropyridine NPY antagonists | NPY1R, NPY2R, NPY5R | SIGMAR1 72/4885KDM4E 1951/4885ALDH1A1 2608/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.