Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.59 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.49 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.46 |
| ▸ | L3MBTL3 | Q96JM7 | 6/20 | 0.46 |
| ▸ | MBTD1 | Q05BQ5 | 5/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 5/20 | 0.46 |
| ▸ | TP53BP1 | Q12888 | 1/20 | 0.43 |
| ▸ | L3MBTL4 | Q8NA19 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7826195 | 0.98 | KDM4E (0.57) | KDM4EALDH1A1ITGB3ITGA2BMAPT | |
| Hydrochloric Acid SCHEMBL27487445 | 0.98 | KDM4E (0.57) | KDM4EALDH1A1ITGB3ITGA2BMAPT | |
| Hydrochloric Acid SCHEMBL6623121 | 0.98 | KDM4E (0.57) | KDM4EALDH1A1ITGB3ITGA2BMAPT | |
| SCHEMBL5173732 | 0.98 | KDM4E (0.56) | KDM4EALDH1A1ITGB3ITGA2BMAPT | |
| Hydrochloric Acid SCHEMBL1373936 | 0.96 | KDM4E (0.55) | KDM4EALDH1A1ITGB3ITGA2BMAPT | |
| Ammonia Solution, Strong SCHEMBL12231017 | 0.85 | SIGMAR1 (0.50) | KDM4EALDH1A1ITGB3ITGA2BMAPT | |
| SCHEMBL7198313 | 0.85 | SIGMAR1 (0.63) | KDM4EALDH1A1MAPTALOX15MEN1 | |
| SCHEMBL6478152 | 0.83 | KDM4E (0.54) | KDM4EALDH1A1MAPTMEN1KMT2A | |
| SCHEMBL12640340 | 0.83 | KDM4E (0.54) | KDM4EALDH1A1MAPTMEN1KMT2A | |
| SCHEMBL3064605 | 0.83 | KDM4E (0.54) | KDM4EALDH1A1ITGB3ITGA2BMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 40 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20030212057-A1 | Substituted piperidines, medicaments containing these compounds, and methods for the production thereof | BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG (DE) | 2003-11-13 | — | — | US | claimed |
| US-7482363-B2 | Piperidine derivatives useful as modulators of chemokine receptor activity | ASTRAZENECA AB (SE) | 2009-01-27 | — | — | US | disclosed |
| EP-1238974-B1 | HETEROCYCLE DERIVATIVES AND DRUGS | NIPPON SHINYAKU CO LTD (JP) | 2007-05-23 | — | — | EP | disclosed |
| US-6949541-B2 | Substituted piperidines, medicaments containing these compounds, and methods for the production thereof | BOEHRINGER INGELHEIM PHARMA KG (DE) | 2005-09-27 | — | — | US | disclosed |
| US-20050182094-A1 | Piperidine derivatives useful as modulators of chemokine receptor activity | ASTRAZENECA AB (SE) | 2005-08-18 | — | — | US | disclosed |
| US-6787546-B2 | POTENT ANTICANCER ACTIVITY; WATER SOLUBLE; INJECTION 4-(2-(2-(N-(4-METHOXYBENZENESULFONYL)-N -PIPERIDINOACETYLAMINO)PHENYL)ETHENYL)PYRIDINE 1-OXIDE HYDROCHLORIDE | NIPPON SHINYAKU CO., LTD. (JP) | 2004-09-07 | — | — | US | disclosed |
| US-20030212057-A1 | Substituted piperidines, medicaments containing these compounds, and methods for the production thereof | BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG (DE) | 2003-11-13 | — | — | US | disclosed |
| US-6596724-B2 | Used in promoting weight loss and treating eating disorders | BRISTOL-MYERS SQUIBB COMPANY | 2003-07-22 | — | — | US | disclosed |
| US-20030022884-A1 | Heterocycle derivatives and drugs | NIPPON SHINYAKU CO., LTD. (JP) | 2003-01-30 | — | — | US | disclosed |
| EP-1238974-A1 | HETEROCYCLE DERIVATIVES AND DRUGS | Nippon Shinyaku Co., Ltd. (JP) | 2002-09-11 | — | — | EP | disclosed |
| EP-0747049-A1 | Use of tachykinin antagonists in combination with serotonin agonists or serotonin reuptake inhibitors for the manufacture of a medicament for the treatment of allergic rhinitis | ELI LILLY AND COMPANY (US) | 1996-12-11 | — | — | EP | disclosed |
| WO-1996029074-A1 | METHODS OF TREATING OR PREVENTING PAIN OR NOCICEPTION | ELI LILLY AND COMPANY (US) | 1996-09-26 | — | — | WO | disclosed |
| WO-1996024353-A1 | METHODS OF TREATING OR PREVENTING PSYCHIATRIC DISORDERS | ELI LILLY AND COMPANY (US) | 1996-08-15 | — | — | WO | disclosed |
| US-5530009-A | TREATING ASTHMA | ELI LILLY AND COMPANY (US) | 1996-06-25 | — | — | US | disclosed |
| EP-0710479-A1 | Use of a serotonin agonist in combination with a tachykinin receptor antagonist for the manufacture of a medicament for the treatment or prevention of migraine | ELI LILLY AND COMPANY (US) | 1996-05-08 | — | — | EP | disclosed |
| WO-1996011000-A1 | METHODS OF TREATING MIGRAINE | ELI LILLY AND COMPANY (US) | 1996-04-18 | — | — | WO | disclosed |
| EP-0699674-A1 | 1-Aryl-2-acetylamidopentanone derivatives for use as tachykinin receptor antagonists | ELI LILLY AND COMPANY (US) | 1996-03-06 | — | — | EP | disclosed |
| WO-1996001819-A1 | HETEROCYCLIC TACHYKININ RECEPTOR ANTAGONISTS | ELI LILLY AND COMPANY (US) | 1996-01-25 | — | — | WO | disclosed |
| EP-0693489-A1 | Heterocyclic tachykinin receptor antagonists | ELI LILLY AND COMPANY (US) | 1996-01-24 | — | — | EP | disclosed |
| EP-0686629-A2 | Cyclohexyl tachykinine receptor antagonists | ELI LILLY AND COMPANY (US) | 1995-12-13 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030212057-A1 | Substituted piperidines, medicaments containing these compounds, and methods for the production thereof | CALCA, CALCRL, P2RY1 | KDM4E 4675/4885ALDH1A1 312/4885ITGB3 2808/4885 |
| US-20050182094-A1 | Piperidine derivatives useful as modulators of chemokine receptor activity | CCR3, CCR1, CCR4 | KDM4E 3935/4885ALDH1A1 812/4885ITGB3 716/4885 |
| US-20030022884-A1 | Heterocycle derivatives and drugs | ABCC5, CYP3A5, CYP2D6 | KDM4E 1826/4885ALDH1A1 137/4885ITGB3 995/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.