Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.52 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.52 |
| ▸ | HPGD | P15428 | 1/20 | 0.52 |
| ▸ | DPP4 | P27487 | 4/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.41 |
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.41 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 6/20 | 0.40 |
| ▸ | GSK3B | P49841 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | NPBWR1 | P48145 | 1/20 | 0.38 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7198334 | 0.91 | MEN1 (0.46) | ALDH1A1CYP1A2CYP2C9HPGDDPP4 | |
| SCHEMBL5093484 | 0.89 | ALDH1A1 (0.47) | ALDH1A1CYP1A2CYP2C9HPGDDPP4 | |
| SCHEMBL5089316 | 0.83 | GSK3B (0.48) | ALDH1A1CYP1A2DPP4KMT2AMEN1 | |
| SCHEMBL7856342 | 0.82 | DPP4 (0.45) | ALDH1A1DPP4MKNK1MKNK2MAPT | |
| SCHEMBL7856343 | 0.82 | DPP4 (0.45) | ALDH1A1DPP4MKNK1MKNK2MAPT | |
| SCHEMBL6085442 | 0.80 | MAPT (0.43) | ALDH1A1DPP4KMT2AMEN1MAPT | |
| SCHEMBL7026103 | 0.80 | GSK3B (0.45) | ALDH1A1CYP1A2DPP4KMT2AMEN1 | |
| SCHEMBL27538023 | 0.79 | GSK3B (0.42) | ALDH1A1CYP1A2DPP4KMT2AMEN1 | |
| SCHEMBL27559775 | 0.79 | GSK3B (0.48) | ALDH1A1CYP1A2DPP4KMT2AMEN1 | |
| SCHEMBL7021102 | 0.79 | GSK3B (0.46) | ALDH1A1DPP4KMT2AMEN1MKNK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7045519-B2 | Inhibitors of glycogen synthase kinase 3 | CHIRON CORPORATION (US) | 2006-05-16 | — | — | US | disclosed |
| US-20020156087-A1 | Inhibitors of glycogen synthase kinase 3 | CHIRON CORPORATION | 2002-10-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020156087-A1 | Inhibitors of glycogen synthase kinase 3 | GSK3B, GSK3A, PYGB | ALDH1A1 3532/4885CYP1A2 2056/4885CYP2C9 2051/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.