Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB1 | P05556 | 4/20 | 0.40 |
| ▸ | ITGA4 | P13612 | 4/20 | 0.40 |
| ▸ | CTSL | P07711 | 1/20 | 0.39 |
| ▸ | PSEN1 | P49768 | 2/20 | 0.37 |
| ▸ | PSEN2 | P49810 | 2/20 | 0.37 |
| ▸ | APH1B | Q8WW43 | 2/20 | 0.37 |
| ▸ | NCSTN | Q92542 | 2/20 | 0.37 |
| ▸ | APH1A | Q96BI3 | 2/20 | 0.37 |
| ▸ | PSENEN | Q9NZ42 | 2/20 | 0.37 |
| ▸ | BACE1 | P56817 | 5/20 | 0.36 |
| ▸ | CTSD | P07339 | 1/20 | 0.36 |
| ▸ | BACE2 | Q9Y5Z0 | 1/20 | 0.36 |
| ▸ | KEAP1 | Q14145 | 4/20 | 0.36 |
| ▸ | CCR1 | P32246 | 1/20 | 0.36 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.35 |
| ▸ | PSMB8 | P28062 | 1/20 | 0.35 |
| ▸ | PSMB9 | P28065 | 1/20 | 0.35 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.35 |
| ▸ | PSMB10 | P40306 | 1/20 | 0.35 |
| ▸ | PSMB2 | P49721 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7198903 | 0.93 | CTSL (0.39) | ITGB1ITGA4CTSLPSEN1PSEN2 | |
| SCHEMBL7197725 | 0.93 | ITGB1 (0.41) | ITGB1ITGA4CTSLPSEN1PSEN2 | |
| SCHEMBL7200493 | 0.90 | ITGB1 (0.43) | ITGB1ITGA4CTSLPSEN1PSEN2 | |
| SCHEMBL7197381 | 0.89 | ITGB1 (0.41) | ITGB1ITGA4CTSLPSEN1PSEN2 | |
| SCHEMBL7198890 | 0.87 | CTSL (0.38) | ITGB1ITGA4CTSLPSEN1PSEN2 | |
| SCHEMBL7196140 | 0.85 | ITGB1 (0.38) | ITGB1ITGA4CTSLPSEN1PSEN2 | |
| SCHEMBL7203259 | 0.84 | ITGB1 (0.36) | ITGB1ITGA4BACE1CCR1 | |
| SCHEMBL7199074 | 0.84 | CCKBR (0.36) | BACE1CCR1 | |
| SCHEMBL7202292 | 0.83 | CTSL (0.38) | ITGB1ITGA4CTSLPSEN1PSEN2 | |
| SCHEMBL7201999 | 0.83 | CTSL (0.38) | ITGB1ITGA4CTSLPSEN1PSEN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6596687-B1 | For treatment of many inflammatory and autoimmune diseases | BIOGEN, INC. | 2003-07-22 | — | — | US | claimed |