Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 3/20 | 0.77 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.77 |
| ▸ | MEN1 | O00255 | 1/20 | 0.77 |
| ▸ | SLCO1B3 | Q9NPD5 | 1/20 | 0.77 |
| ▸ | SLCO1B1 | Q9Y6L6 | 1/20 | 0.77 |
| ▸ | USP2 | O75604 | 1/20 | 0.77 |
| ▸ | GPBAR1 | Q8TDU6 | 10/20 | 0.72 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.72 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.72 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.70 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.70 |
| ▸ | LMNA | P02545 | 1/20 | 0.67 |
| ▸ | CYP8B1 | Q9UNU6 | 1/20 | 0.66 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.65 |
| ▸ | CA1 | P00915 | 1/20 | 0.62 |
| ▸ | CA2 | P00918 | 1/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7196373 | 1.00 | CYP3A4 (0.77) | CYP3A4KMT2AMEN1SLCO1B3SLCO1B1 | |
| SCHEMBL31300108 | 0.91 | CYP3A4 (0.75) | CYP3A4KMT2AMEN1SLCO1B3SLCO1B1 | |
| SCHEMBL721724 | 0.90 | CYP3A4 (0.74) | CYP3A4KMT2AMEN1SLCO1B3SLCO1B1 | |
| SCHEMBL14871096 | 0.89 | CYP3A4 (0.78) | CYP3A4KMT2AMEN1SLCO1B3SLCO1B1 | |
| SCHEMBL197081 | 0.89 | CYP3A4 (0.78) | CYP3A4KMT2AMEN1SLCO1B3SLCO1B1 | |
| Cholic Acid SCHEMBL7499949 | 0.88 | GPBAR1 (0.82) | CYP3A4KMT2AMEN1SLCO1B3SLCO1B1 | |
| SCHEMBL16500842 | 0.87 | CYP3A4 (0.78) | CYP3A4KMT2AMEN1SLCO1B3SLCO1B1 | |
| SCHEMBL13360010 | 0.87 | CYP3A4 (0.72) | CYP3A4KMT2AMEN1SLCO1B3SLCO1B1 | |
| SCHEMBL13260937 | 0.87 | CYP3A4 (0.78) | CYP3A4KMT2AMEN1SLCO1B3SLCO1B1 | |
| SCHEMBL5438281 | 0.87 | CYP3A4 (0.80) | CYP3A4KMT2AMEN1SLCO1B3SLCO1B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6589946-B2 | Conjugated to one or two fatty acids via a nitrogen bridge; may also be conjugated to an amino acid; use in dissolving cholesterol gallstones and reducing or preventing arteriosclerosis | GALMED INTERNATIONAL LIMITED (MT) | 2003-07-08 | — | — | US | disclosed |
| EP-1071702-B1 | FATTY ACID DERIVATIVES OF BILE ACIDS AND BILE ACID DERIVATIVES | GALMED INT LTD (MT) | 2002-08-28 | — | — | EP | disclosed |
| US-20020091111-A1 | Bile salt conjugates | GALMED INTERNATIONAL LIMITED | 2002-07-11 | — | — | US | disclosed |
| US-6384024-B1 | CONJUGATED AMINO ACID AND BILE ACID GALLSTONES IN BILE, PREVENTING THEIR OCCURRENCE OR RECURRENCE, TO THEIR USE IN REDUCING OR PREVENTING ARTERIOSCLEROSIS | GALMED INTERNATIONAL LIMITED (MT) | 2002-05-07 | — | — | US | disclosed |
| EP-1071702-A1 | FATTY ACID DERIVATIVES OF BILE ACIDS AND BILE ACID DERIVATIVES | Galmed International Ltd. (MT) | 2001-01-31 | — | — | EP | disclosed |
| WO-1999052932-A1 | FATTY ACID DERIVATIVES OF BILE ACIDS AND BILE ACID DERIVATIVES | GALMED INTERNATIONAL LTD. (MT) | 1999-10-21 | — | — | WO | disclosed |