Phosphoric Acid — predicted protein targets

Known targets — ChEMBL curated mechanism

ADRA1A ADRA1B ADRA1D ADRB1 ADRB2 ADRB3 CYP11B1 DPP4 FGFR1 FGFR2 FGFR3 FGFR4 HRH1 JAK1 JAK2 JAK3 KCNA1 KCNA10 KCNA2 KCNA3 KCNA4 KCNA5 KCNA6 KCNA7 KCNB1 KCNB2 KCNC1 KCNC2 KCNC3 KCNC4 KCND1 KCND2 KCND3 KCNF1 KCNG1 KCNG2 KCNG3 KCNG4 KCNH1 KCNH2 KCNH3 KCNH4 KCNH5 KCNH6 KCNH7 KCNH8 KCNQ1 KCNQ2 KCNQ3 KCNQ4 KCNQ5 KCNS1 KCNS2 KCNS3 KCNV1 KCNV2 KDR KIT NA OPRD1 OPRK1 OPRM1 P PDGFRB PIK3CD SCN10A SCN11A SCN1A SCN2A SCN3A SCN4A SCN5A SCN7A SCN8A SCN9A SMO TYK2 pol rplA rplB rplC rplD rplE rplF rplJ rplK rplL rplM rplN rplO rplP rplQ rplR rplS rplT rplU rplV rplW rplX rplY rpmA rpmB rpmC rpmD rpmE rpmF rpmG rpmH rpmI rpmJ rpsA rpsB rpsC rpsD rpsE rpsF rpsG rpsH rpsI rpsJ rpsK rpsL rpsM rpsN rpsO rpsP rpsQ rpsR rpsS rpsT rpsU ykgM ykgO

The experimentally established mechanism targets of Phosphoric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

	gene	UniProt	supporting neighbours	confidence
▸	PNP	P00491	1/20	0.50

▸	HSPA5	P11021	2/20	0.49

▸	HSPA8	P11142	2/20	0.49

▸	MEN1	O00255	1/20	0.48

▸	KMT2A	Q03164	1/20	0.48

▸	FBP1	P09467	1/20	0.46

▸	CYP1A2	P05177	1/20	0.45

▸	LMNA	P02545	4/20	0.44

▸	SMN1; SMN2	Q16637	3/20	0.44

▸	ALDH1A1	P00352	2/20	0.44

▸	MTOR	P42345	2/20	0.44

▸	TP53	P04637	2/20	0.44

▸	HBB	P68871	2/20	0.44

▸	POLB	P06746	1/20	0.44

▸	GMNN	O75496	1/20	0.44

▸	NFKB1	P19838	1/20	0.44

▸	DNMT1	P26358	1/20	0.44

▸	THPO	P40225	1/20	0.44

▸	HTT	P42858	1/20	0.44

▸	RAB9A	P51151	1/20	0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
SCHEMBL10661591	0.96	PNP (0.54)	PNPHSPA5HSPA8MEN1KMT2A
SCHEMBL10814753	0.96	PNP (0.54)	PNPHSPA5HSPA8MEN1KMT2A
SCHEMBL10814776	0.96	PNP (0.54)	PNPHSPA5HSPA8MEN1KMT2A
SCHEMBL7948397	0.96	PNP (0.54)	PNPHSPA5HSPA8MEN1KMT2A
SCHEMBL375987	0.96	PNP (0.54)	PNPHSPA5HSPA8MEN1KMT2A
SCHEMBL132928	0.96	PNP (0.54)	PNPHSPA5HSPA8MEN1KMT2A
SCHEMBL2185987	0.96	PNP (0.54)	PNPHSPA5HSPA8MEN1KMT2A
SCHEMBL132926	0.96	PNP (0.54)	PNPHSPA5HSPA8MEN1KMT2A
SCHEMBL10496354	0.96	PNP (0.54)	PNPHSPA5HSPA8MEN1KMT2A
SCHEMBL8789685	0.96	PNP (0.54)	PNPHSPA5HSPA8MEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
US-6593306-B1	Prematurely shortening a telomere in a cell comprising administering to said cell in an animal in an amount of 7-deaza nucleoside in an amount sufficient to inhibit telomere extension, reduced proliferative capacity leads to cell death	BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEMS	2003-07-15	—	—	US	disclosed
US-6054442-A	THE INCORPORATION OF NUCLEOTIDE ANALOGS, SUCH AS 7-DEAZA-2'-DEOXYQUANOSINE-5'-TRIPHOSPHATE AFFECTED THE PROCESSIVITY OF TELOMERASE, CONVERTING PROCESSIVE TELOMERASE TO NON-PROCESSIVE TELOMERASE.	BOARD OF REGENTS, UNIVERSITY OF TEXAS SYSTEM	2000-04-25	—	—	US	disclosed
US-6004939-A	INHIBITING CELL GROWTH WITH 7-DEAZA-2*-DEOXYNUCLEOSIDE; ANTICARCINOGENIC AGENTS	CTRC RESEARCH FOUNDATION BOARD OF REGENTS (US)	1999-12-21	—	—	US	disclosed
WO-1997002279-A1	METHODS AND COMPOSITIONS FOR MODULATION AND INHIBITION OF TELOMERASE	CTRC RESEARCH FOUNDATION (US)	1997-01-23	—	—	WO	disclosed