Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PNP | P00491 | 1/20 | 0.54 |
| ▸ | HSPA5 | P11021 | 2/20 | 0.53 |
| ▸ | HSPA8 | P11142 | 2/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 3/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | MTOR | P42345 | 2/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | GMNN | O75496 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.47 |
| ▸ | DNMT1 | P26358 | 1/20 | 0.47 |
| ▸ | THPO | P40225 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | BLM | P54132 | 1/20 | 0.47 |
| ▸ | HBB | P68871 | 1/20 | 0.47 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8789685 | 1.00 | PNP (0.54) | PNPHSPA5HSPA8MEN1KMT2A | |
| SCHEMBL2185987 | 1.00 | PNP (0.54) | PNPHSPA5HSPA8MEN1KMT2A | |
| SCHEMBL10661591 | 1.00 | PNP (0.54) | PNPHSPA5HSPA8MEN1KMT2A | |
| SCHEMBL10814753 | 1.00 | PNP (0.54) | PNPHSPA5HSPA8MEN1KMT2A | |
| SCHEMBL10496354 | 1.00 | PNP (0.54) | PNPHSPA5HSPA8MEN1KMT2A | |
| SCHEMBL10814776 | 1.00 | PNP (0.54) | PNPHSPA5HSPA8MEN1KMT2A | |
| SCHEMBL132926 | 1.00 | PNP (0.54) | PNPHSPA5HSPA8MEN1KMT2A | |
| SCHEMBL375987 | 1.00 | PNP (0.54) | PNPHSPA5HSPA8MEN1KMT2A | |
| SCHEMBL7948397 | 1.00 | PNP (0.54) | PNPHSPA5HSPA8MEN1KMT2A | |
| Phosphoric Acid SCHEMBL7200240 | 0.96 | PNP (0.50) | PNPHSPA5HSPA8MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 61 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1414854-B | Phosphonate compounds | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA SAN DIEGO (US) | 2015-08-19 | — | — | CN | claimed |
| EP-1914237-B1 | Phosphonate ester antiviral compounds | UNIV CALIFORNIA (US) | 2014-06-18 | — | — | EP | claimed |
| EP-1233770-B1 | PHOSPHONATE COMPOUNDS | UNIV CALIFORNIA AT SAN DIEGO (US) | 2008-02-13 | — | — | EP | claimed |
| US-20060281706-A1 | New phosphonate ester derivatives of drugs such as antivirals cidofovir, adefovir, tenofovir, azidothymidine (AZT), or bisphosphonates such as alendronate, or anticancers such as cytosine arabinoside; side effect reduction, less toxic; antiviral | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2006-12-14 | — | — | US | claimed |
| US-7098197-B2 | An antiviral nucleoside in which the 5'-hydroxyl group has been substituted for a phosphonate or methyl phosphonate that is covalently linked to an alkylethanediol; osteoporosis; anticarcinogenic agents; viricides | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2006-08-29 | — | — | US | claimed |
| WO-2005090370-A1 | PHARMACOLOGICALLY ACTIVE AGENTS CONTAINING ESTERIFIED PHOSPHONATES AND METHODS FOR USE THEREOF | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2005-09-29 | — | — | WO | claimed |
| US-20050192246-A1 | Pharmacologically active agents containing esterified phosphonates and methods for use thereof | US ARMY, SECRETARY OF THE ARMY | 2005-09-01 | — | — | US | claimed |
| US-20050182019-A1 | An antiviral nucleoside in which the 5'-hydroxyl group has been substituted for a phosphonate or methyl phosphonate that is covalently linked to an alkylethanediol; osteoporosis; anticarcinogenic agents; viricides | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2005-08-18 | — | — | US | claimed |
| US-20040127735-A1 | New phosphonate ester derivatives of drugs such as antivirals cidofovir, adefovir, tenofovir, azidothymidine (AZT), or bisphosphonates such as alendronate, or anticancers such as cytosine arabinoside; side effect reduction, less toxic; antiviral | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2004-07-01 | — | — | US | claimed |
| US-20040019232-A1 | Analogs of phosphonate and bisphosphonate compounds based on bone resorption suppressors (alendronic acid), viricides (cidofovir) and antineoplastic agents (bemcitabine); nontoxic; bioavailability; side effects reduction | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2004-01-29 | — | — | US | claimed |
| EP-1233770-A4 | PHOSPHONATE COMPOUNDS | UNIV CALIFORNIA AT SAN DIEGO (US) | 2003-04-16 | — | — | EP | claimed |
| EP-1233770-A2 | PHOSPHONATE COMPOUNDS | The Regents of The University of California at San Diego (US) | 2002-08-28 | — | — | EP | claimed |
| WO-2001039724-A2 | PHOSPHONATE COMPOUNDS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN DIEGO (US) | 2001-06-07 | — | — | WO | claimed |
| US-10071110-B2 | Phosphonate compounds | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2018-09-11 | — | — | US | disclosed |
| US-20170239279-A1 | PHOSPHONATE COMPOUNDS | UNIV CALIFORNIA (US) | 2017-08-24 | — | — | US | disclosed |
| US-9649321-B2 | Phosphonate compounds | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2017-05-16 | — | — | US | disclosed |
| EP-1233770-A2 | PHOSPHONATE COMPOUNDS | The Regents of The University of California at San Diego (US) | 2002-08-28 | — | — | EP | disclosed |
| EP-1137764-A1 | NEW MEDICAL USE OF GENE AND VECTOR ENCODING A MULTISUBSTRATE DEOXYRIBONUCLEOSIDASE | Biovici (CH) | 2001-10-04 | — | — | EP | disclosed |
| WO-2001039724-A2 | PHOSPHONATE COMPOUNDS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN DIEGO (US) | 2001-06-07 | — | — | WO | disclosed |
| WO-2000036099-A1 | NEW MEDICAL USE OF GENE AND VECTOR ENCODING A MULTISUBSTRATE DEOXYRIBONUCLEOSIDASE | BIOVICI (CH) | 2000-06-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10071110-B2 | Phosphonate compounds | PHPT1, PHOSPHO1, PIK3CA | PNP 74/4885HSPA5 4527/4885HSPA8 4433/4885 |
| US-20060281706-A1 | New phosphonate ester derivatives of drugs such as antivirals cidofovir, adefovir, tenofovir, azidothymidine (AZT), or bisphosphonates such as alendronate, or anticancers such as cytosine arabinoside; side effect reduction, less toxic; antiviral | TYMP, ADA, DCTD | PNP 19/4885HSPA5 4188/4885HSPA8 4579/4885 |
| US-20040127735-A1 | New phosphonate ester derivatives of drugs such as antivirals cidofovir, adefovir, tenofovir, azidothymidine (AZT), or bisphosphonates such as alendronate, or anticancers such as cytosine arabinoside; side effect reduction, less toxic; antiviral | TYMP, ADA, DCTD | PNP 19/4885HSPA5 4188/4885HSPA8 4579/4885 |
| US-20040019232-A1 | Analogs of phosphonate and bisphosphonate compounds based on bone resorption suppressors (alendronic acid), viricides (cidofovir) and antineoplastic agents (bemcitabine); nontoxic; bioavailability; side effects reduction | BPGM, PPA1, INPP5D | PNP 96/4885HSPA5 3800/4885HSPA8 4395/4885 |
| US-20170239279-A1 | PHOSPHONATE COMPOUNDS | PHPT1, PHOSPHO1, PIK3CA | PNP 74/4885HSPA5 4527/4885HSPA8 4433/4885 |
| US-20050192246-A1 | Pharmacologically active agents containing esterified phosphonates and methods for use thereof | PHPT1, PPIP5K2, PHOSPHO1 | PNP 30/4885HSPA5 4130/4885HSPA8 4178/4885 |
| US-20050182019-A1 | An antiviral nucleoside in which the 5'-hydroxyl group has been substituted for a phosphonate or methyl phosphonate that is covalently linked to an alkylethanediol; osteoporosis; anticarcinogenic agents; viricides | MTAP, SAMHD1, NT5C3B | PNP 9/4885HSPA5 4510/4885HSPA8 3975/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.