Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | TACR3 | P29371 | 17/20 | 0.49 |
| ▸ | KCNH2 | Q12809 | 6/20 | 0.49 |
| ▸ | TACR2 | P21452 | 11/20 | 0.49 |
| ▸ | OPRM1 | P35372 | 6/20 | 0.47 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5931058 | 0.79 | TACR3 (0.74) | TACR3TACR2OPRM1 | |
| SCHEMBL5931060 | 0.79 | TACR3 (0.74) | TACR3TACR2OPRM1 | |
| SCHEMBL5049830 | 0.78 | LMNA (0.67) | LMNATACR3TACR2OPRM1 | |
| SCHEMBL4667053 | 0.78 | TACR3 (0.55) | LMNATACR3KCNH2TACR2OPRM1 | |
| SCHEMBL5047970 | 0.76 | LMNA (0.67) | LMNATACR3TACR2OPRM1 | |
| SCHEMBL6996768 | 0.76 | LMNA (0.63) | LMNATACR3KCNH2TACR2OPRM1 | |
| SCHEMBL3870523 | 0.74 | LMNA (0.65) | LMNATACR3TACR2OPRM1 | |
| SCHEMBL4668093 | 0.73 | LMNA (0.65) | LMNATACR3TACR2 | |
| SCHEMBL7164730 | 0.73 | TACR3 (0.60) | TACR3KCNH2TACR2OPRM1TRPV4 | |
| SCHEMBL16553849 | 0.73 | LMNA (0.67) | LMNATACR3TACR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1334088-A1 | QUINOLINE-4-CARBOXAMIDE DERIVATIVES AS NK-3 AND NK-2 RECEPTOR ANTAGONISTS | GlaxoSmithKline S.p.A. (IT) | 2003-08-13 | — | — | EP | disclosed |
| WO-2002038548-A1 | QUINOLINE-4-CARBOXAMIDE DERIVATIVES AS NK-3 AND NK-2 RECEPTOR ANTAGONISTS | GLAXOSMITHKLINE S.P.A. (IT) | 2002-05-16 | — | — | WO | disclosed |