Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 11/20 | 0.55 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.50 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.50 |
| ▸ | ACHE | P22303 | 1/20 | 0.50 |
| ▸ | RAD52 | P43351 | 1/20 | 0.50 |
| ▸ | LTA4H | P09960 | 1/20 | 0.49 |
| ▸ | PTGIR | P43119 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | MBTD1 | Q05BQ5 | 1/20 | 0.47 |
| ▸ | L3MBTL3 | Q96JM7 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6057540 | 0.89 | HRH3 (0.68) | HRH3CYP2D6CYP2C19HRH4ALDH1A1 | |
| SCHEMBL6057466 | 0.88 | HRH3 (0.71) | HRH3TSHRCYP2D6CYP2C19HRH4 | |
| SCHEMBL6057519 | 0.86 | HRH3 (0.77) | HRH3 | |
| SCHEMBL6057447 | 0.86 | HRH3 (0.75) | HRH3TSHRCYP2D6CYP2C19HRH4 | |
| SCHEMBL6058205 | 0.86 | HRH3 (0.75) | HRH3TSHRCYP2D6CYP2C19HRH4 | |
| SCHEMBL3041586 | 0.77 | ALDH1A1 (0.69) | HRH3TSHRHRH4ACHERAD52 | |
| SCHEMBL6057443 | 0.77 | ALDH1A1 (0.58) | HRH3TSHRHRH4ACHERAD52 | |
| SCHEMBL3041814 | 0.76 | HRH3 (0.57) | HRH3TSHRHRH4ACHERAD52 | |
| SCHEMBL11201497 | 0.75 | HRH3 (0.94) | HRH3CYP2D6CYP2C19HRH4ALDH1A1 | |
| SCHEMBL4419477 | 0.74 | ALDH1A1 (0.63) | HRH3TSHRCYP2D6CYP2C19ACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1311499-A2 | BICYCLIC COMPOUNDS AS H3 RECEPTOR LIGANDS | Ortho-McNeil Pharmaceutical, Inc. (US) | 2003-05-21 | — | — | EP | disclosed |
| WO-2002012224-A2 | BICYCLIC COMPOUNDS AS H3 RECEPTOR LIGANDS | ORTHO MCNEIL PHARMACEUTICAL, INC. (US) | 2002-02-14 | — | — | WO | disclosed |