Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | RECQL | P46063 | 2/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.39 |
| ▸ | CASP1 | P29466 | 1/20 | 0.39 |
| ▸ | BLM | P54132 | 1/20 | 0.39 |
| ▸ | CASP7 | P55210 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 3/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | KIF11 | P52732 | 1/20 | 0.37 |
| ▸ | HTR2A | P28223 | 1/20 | 0.37 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28245955 | 0.86 | TSHR (0.38) | ALDH1A1MAPTRECQLTDP1HDAC9 | |
| SCHEMBL28008400 | 0.80 | HDAC9 (0.41) | ALDH1A1MAPTRECQLTDP1KDM4E | |
| SCHEMBL27852609 | 0.79 | ALDH1A1 (0.41) | ALDH1A1MAPTRECQLTDP1KDM4E | |
| SCHEMBL28246686 | 0.79 | KDM4E (0.38) | ALDH1A1MAPTRECQLTDP1KDM4E | |
| SCHEMBL28312964 | 0.78 | TDP1 (0.40) | ALDH1A1MAPTRECQLTDP1KDM4E | |
| SCHEMBL9845298 | 0.77 | ALDH1A1 (0.60) | ALDH1A1MAPTRECQLTDP1KDM4E | |
| SCHEMBL27969858 | 0.77 | MEN1 (0.40) | ALDH1A1MAPTRECQLTDP1KDM4E | |
| SCHEMBL28008899 | 0.77 | ALDH1A1 (0.39) | ALDH1A1MAPTRECQLTDP1KDM4E | |
| Hydrochloric Acid SCHEMBL8017746 | 0.75 | ALDH1A1 (0.59) | ALDH1A1MAPTRECQLTDP1KDM4E | |
| SCHEMBL27956103 | 0.75 | HDAC9 (0.43) | ALDH1A1MAPTRECQLTDP1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6608193-B2 | Forming an intermediate by reacting the support-bound amino-substituted-tetrahydroisoquinoline compound with a reagent; and cyclizatively cleaving support-bound amino-substituted-tetrahydroisoquinoline compound | THE PROCTER & GAMBLE COMPANY | 2003-08-19 | — | — | US | disclosed |
| US-6566524-B2 | Providing amino-substituted-tetrahydroisoquinoline-carboxylate attached to a solid support; reacting with sulfonyl chloride compound; cleaving intermediate from solid support to form an amino-tetrahydroisoquinoline-sulfonamide hydroxamic acid | THE PROCTER & GAMBLE CO. | 2003-05-20 | — | — | US | disclosed |
| US-20020077480-A1 | Methods for synthesis of amino-tetrahydroisoquinoline ring compounds | PROCTER & GAMBLE COMPANY, THE | 2002-06-20 | — | — | US | disclosed |
| US-20020058815-A1 | Methods for synthesis of amino-tertahydroisoquinoline-sulfonamide hydroxamic acids | PROCTER & GAMBLE COMANY, THE | 2002-05-16 | — | — | US | disclosed |
| US-20020055637-A1 | Methods for synthesis of amino-tetrahydroisoquinoline-carboxylic acids | PROCTER & GAMBLE COMPANY, THE | 2002-05-09 | — | — | US | disclosed |
| US-20020055637-A1 | Methods for synthesis of amino-tetrahydroisoquinoline-carboxylic acids | PROCTER & GAMBLE COMPANY, THE | 2002-05-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020055637-A1 | Methods for synthesis of amino-tetrahydroisoquinoline-carboxylic acids | DAO, DDC, ASNS | ALDH1A1 1023/4885MAPT 2226/4885RECQL 331/4885 |
| US-20020077480-A1 | Methods for synthesis of amino-tetrahydroisoquinoline ring compounds | ASNS, QPCT, DAO | ALDH1A1 3610/4885MAPT 1453/4885RECQL 240/4885 |
| US-20020058815-A1 | Methods for synthesis of amino-tertahydroisoquinoline-sulfonamide hydroxamic acids | ASNS, GLUL, STS | ALDH1A1 2577/4885MAPT 4493/4885RECQL 1011/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.