Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA1 | P30542 | 8/20 | 0.56 |
| ▸ | ADORA2A | P29274 | 7/20 | 0.56 |
| ▸ | ADORA3 | P0DMS8 | 7/20 | 0.56 |
| ▸ | ADORA2B | P29275 | 4/20 | 0.51 |
| ▸ | HTR2C | P28335 | 2/20 | 0.50 |
| ▸ | TMIGD3 | P0DMS9 | 1/20 | 0.50 |
| ▸ | HTR2B | P41595 | 1/20 | 0.50 |
| ▸ | NT5E | P21589 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7208637 | 0.90 | ADORA3 (0.57) | ADORA1ADORA2AADORA3ADORA2BHTR2C | |
| SCHEMBL6796905 | 0.87 | ADORA1 (0.56) | ADORA1ADORA2AADORA3ADORA2BHTR2C | |
| SCHEMBL7205475 | 0.86 | ADORA1 (0.45) | ADORA1ADORA2AADORA3ADORA2BHTR2C | |
| SCHEMBL7569540 | 0.85 | ADORA2A (0.51) | ADORA1ADORA2AADORA3ADORA2B | |
| SCHEMBL8090571 | 0.84 | ADORA3 (0.58) | ADORA1ADORA2AADORA3ADORA2BHTR2C | |
| SCHEMBL3914182 | 0.84 | ADORA3 (0.58) | ADORA1ADORA2AADORA3ADORA2BHTR2C | |
| SCHEMBL3914192 | 0.84 | ADORA3 (0.58) | ADORA1ADORA2AADORA3ADORA2BHTR2C | |
| SCHEMBL7211345 | 0.84 | ADORA2A (0.54) | ADORA1ADORA2AADORA3ADORA2BNT5E | |
| Formic Acid SCHEMBL6574863 | 0.84 | ADORA1 (0.52) | ADORA1ADORA2AADORA3ADORA2BHTR2C | |
| SCHEMBL6878900 | 0.84 | ADORA3 (0.55) | ADORA1ADORA2AADORA3ADORA2BHTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6610665-B1 | Treatment of inflammatory diseases, asthma or chronic obstructive pulmonary disease | SMITHKLINE BEECHAM CORPORATION | 2003-08-26 | — | — | US | disclosed |
| EP-1056759-B1 | 2-(PURIN-9-YL) -TETRAHYDROFURAN-3, 4-DIOL DERIVATIVES | GLAXO GROUP LTD (GB) | 2002-09-04 | — | — | EP | disclosed |
| EP-1056759-A1 | 2-(PURIN-9-YL) -TETRAHYDROFURAN-3, 4-DIOL DERIVATIVES | GLAXO GROUP LIMITED (GB) | 2000-12-06 | — | — | EP | disclosed |
| WO-1999041267-A1 | 2-(PURIN-9-YL) -TETRAHYDROFURAN-3, 4-DIOL DERIVATIVES | GLAXO GROUP LIMITED (GB) | 1999-08-19 | — | — | WO | disclosed |