Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 7/20 | 0.61 |
| ▸ | DRD3 | P35462 | 3/20 | 0.61 |
| ▸ | ADRB1 | P08588 | 6/20 | 0.54 |
| ▸ | HTR3E | A5X5Y0 | 3/20 | 0.54 |
| ▸ | HTR3B | O95264 | 3/20 | 0.54 |
| ▸ | HTR3A | P46098 | 3/20 | 0.54 |
| ▸ | HTR3D | Q70Z44 | 3/20 | 0.54 |
| ▸ | HTR3C | Q8WXA8 | 3/20 | 0.54 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.54 |
| ▸ | HTR1A | P08908 | 2/20 | 0.53 |
| ▸ | HTR7 | P34969 | 2/20 | 0.53 |
| ▸ | HTR5A | P47898 | 1/20 | 0.50 |
| ▸ | HTR2C | P28335 | 2/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | THRB | P10828 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | HTR2A | P28223 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3239201 | 0.74 | ADRB1 (0.47) | HTR6DRD3ADRB1HTR3EHTR3B | |
| SCHEMBL5349708 | 0.73 | HTR6 (0.51) | HTR6DRD3ADRB1HTR3EHTR3B | |
| SCHEMBL24011964 | 0.73 | MAP3K14 (0.51) | SIGMAR1HTR2CCYP1A2CYP3A4CYP2D6 | |
| SCHEMBL2097897 | 0.73 | ESR2 (0.46) | DRD3HTR2ADRD2 | |
| Phenylpiperazine SCHEMBL27858598 | 0.73 | ADRB1 (1.00) | HTR6ADRB1HTR3EHTR3BHTR3A | |
| Phenylpiperazine SCHEMBL24889 | 0.73 | ADRB1 (1.00) | HTR6ADRB1HTR3EHTR3BHTR3A | |
| Phenylpiperazine SCHEMBL29135595 | 0.73 | ADRB1 (1.00) | HTR6ADRB1HTR3EHTR3BHTR3A | |
| Phenylpiperazine SCHEMBL55125 | 0.73 | ADRB1 (1.00) | HTR6ADRB1HTR3EHTR3BHTR3A | |
| Hydrochloric Acid SCHEMBL7235786 | 0.72 | NPC1 (0.54) | HTR6DRD3ADRB1HTR3EHTR3B | |
| Phenylpiperazine SCHEMBL29235019 | 0.72 | ADRB1 (0.80) | HTR6DRD3ADRB1HTR3EHTR3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6599904-B2 | 5-HT6 receptor antagonists are believed to be of potential use in the treatment of certain CNS disorders; cognitive memory enhancement | SMITHKLINE BEECHAM P.L.C. (GB) | 2003-07-29 | — | — | US | disclosed |