SCHEMBL7202295

SCHEMBL7202295

Nn1cc(C=O)c2ccccc21

nearest known ligand 0.61

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 12/20 0.61
IMPDH2 P12268 1/20 0.61
KDM4E B2RXH2 2/20 0.53
SMN1; SMN2 Q16637 8/20 0.51
HTT P42858 6/20 0.51
UBE2N P61088 1/20 0.47
KMT2A Q03164 2/20 0.47
MAPT P10636 2/20 0.47
MEN1 O00255 1/20 0.46
LMNA P02545 4/20 0.45
NPC1 O15118 1/20 0.45
HPGD P15428 1/20 0.45
RAB9A P51151 1/20 0.45
TDP1 Q9NUW8 2/20 0.44
POLB P06746 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5545120 0.80 ALDH1A1 (0.61) ALDH1A1IMPDH2KDM4ESMN1; SMN2HTT
SCHEMBL27804409 0.80 ALDH1A1 (0.61) ALDH1A1IMPDH2KDM4ESMN1; SMN2HTT
SCHEMBL3831676 0.76 ALDH1A1 (0.61) ALDH1A1IMPDH2KDM4ESMN1; SMN2HTT
SCHEMBL1828339 0.76 ALDH1A1 (0.61) ALDH1A1IMPDH2KDM4ESMN1; SMN2HTT
SCHEMBL16067290 0.76 ALDH1A1 (0.61) ALDH1A1IMPDH2KDM4ESMN1; SMN2HTT
SCHEMBL5503150 0.76 ALDH1A1 (0.61) ALDH1A1IMPDH2KDM4ESMN1; SMN2HTT
SCHEMBL29365374 0.76 ALDH1A1 (1.00) ALDH1A1IMPDH2KDM4ESMN1; SMN2HTT
SCHEMBL378958 0.76 ALDH1A1 (1.00) ALDH1A1IMPDH2KDM4ESMN1; SMN2HTT
SCHEMBL2187571 0.76 ALDH1A1 (0.63) ALDH1A1IMPDH2SMN1; SMN2HTTKMT2A
Water SCHEMBL27751444 0.74 ALDH1A1 (0.96) ALDH1A1IMPDH2KDM4ESMN1; SMN2HTT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1021200-A1 METHODS AND COMPOSITIONS FOR TREATING RHEUMATOID ARTHRITIS BASF AKTIENGESELLSCHAFT (DE) 2000-07-26 EP claimed
EP-0981358-A1 DOLASTATIN-15 DERIVATIVES IN COMBINATION WITH TAXANES BASF AKTIENGESELLSCHAFT (DE) 2000-03-01 EP claimed
WO-1999017792-A1 METHODS AND COMPOSITIONS FOR TREATING RHEUMATOID ARTHRITIS BASF AKTIENGESELLSCHAFT (DE) 1999-04-15 WO claimed
WO-1999017709-A2 METHODS AND COMPOSITIONS FOR TREATING RHEUMATOID ARTHRITIS BASF AKTIENGESELLSCHAFT (DE) 1999-04-15 WO claimed
WO-1998040092-A1 DOLASTATIN-15 DERIVATIVES IN COMBINATION WITH TAXANES BASF AKTIENGESELLSCHAFT (DE) 1998-09-17 WO claimed
EP-0981358-B1 DOLASTATIN-15 DERIVATIVES IN COMBINATION WITH TAXANES BASF AG (DE) 2003-05-28 EP disclosed
EP-0871656-B1 DOLASTATIN DERIVATIVES, THEIR PREPARATION AND USE ABBOTT GMBH & CO KG (DE) 2002-09-25 EP disclosed
EP-1021200-A1 METHODS AND COMPOSITIONS FOR TREATING RHEUMATOID ARTHRITIS BASF AKTIENGESELLSCHAFT (DE) 2000-07-26 EP disclosed
EP-0981358-A1 DOLASTATIN-15 DERIVATIVES IN COMBINATION WITH TAXANES BASF AKTIENGESELLSCHAFT (DE) 2000-03-01 EP disclosed
WO-1999017792-A1 METHODS AND COMPOSITIONS FOR TREATING RHEUMATOID ARTHRITIS BASF AKTIENGESELLSCHAFT (DE) 1999-04-15 WO disclosed
WO-1999017709-A2 METHODS AND COMPOSITIONS FOR TREATING RHEUMATOID ARTHRITIS BASF AKTIENGESELLSCHAFT (DE) 1999-04-15 WO disclosed
WO-1998040092-A1 DOLASTATIN-15 DERIVATIVES IN COMBINATION WITH TAXANES BASF AKTIENGESELLSCHAFT (DE) 1998-09-17 WO disclosed
EP-0642530-A1 DERIVATIVES OF DOLASTATIN BASF Aktiengesellschaft (DE) 1995-03-15 EP disclosed