Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 10/20 | 0.61 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.61 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.47 |
| ▸ | HTT | P42858 | 4/20 | 0.47 |
| ▸ | UBE2N | P61088 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 3/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | PIM1 | P11309 | 3/20 | 0.44 |
| ▸ | PIM3 | Q86V86 | 3/20 | 0.44 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30078684 | 0.77 | ALDH1A1 (0.58) | ALDH1A1IMPDH2KDM4ESMN1; SMN2HTT | |
| SCHEMBL24831720 | 0.77 | ALDH1A1 (0.58) | ALDH1A1IMPDH2KDM4ESMN1; SMN2HTT | |
| SCHEMBL27804409 | 0.76 | ALDH1A1 (0.61) | ALDH1A1IMPDH2KDM4ESMN1; SMN2HTT | |
| SCHEMBL16067290 | 0.76 | ALDH1A1 (0.61) | ALDH1A1IMPDH2KDM4ESMN1; SMN2HTT | |
| SCHEMBL3831676 | 0.76 | ALDH1A1 (0.61) | ALDH1A1IMPDH2KDM4ESMN1; SMN2HTT | |
| SCHEMBL5503150 | 0.76 | ALDH1A1 (0.61) | ALDH1A1IMPDH2KDM4ESMN1; SMN2HTT | |
| SCHEMBL378958 | 0.76 | ALDH1A1 (1.00) | ALDH1A1IMPDH2KDM4ESMN1; SMN2HTT | |
| SCHEMBL7202295 | 0.76 | ALDH1A1 (0.61) | ALDH1A1IMPDH2KDM4ESMN1; SMN2HTT | |
| SCHEMBL29365374 | 0.76 | ALDH1A1 (1.00) | ALDH1A1IMPDH2KDM4ESMN1; SMN2HTT | |
| SCHEMBL5545120 | 0.76 | ALDH1A1 (0.61) | ALDH1A1IMPDH2KDM4ESMN1; SMN2HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110230419-A1 | IAP BINDING COMPOUNDS | NUEVOLUTION A/S (DK) | 2011-09-22 | — | — | US | disclosed |
| EP-2318363-A1 | HETEROCYCLIC DERIVATIVES AS IAP BINDING COMPOUNDS | Nuevolution A/S (DK) | 2011-05-11 | — | — | EP | disclosed |
| WO-2009152824-A1 | HETEROCYCLIC DERIVATIVES AS IAP BINDING COMPOUNDS | NUEVOLUTION A/S (DK) | 2009-12-23 | — | — | WO | disclosed |
| EP-1710234-A1 | MALONONITRILE COMPOUND AND USE THEREOF | Sumitomo Chemical Company, Limited (JP) | 2006-10-11 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110230419-A1 | IAP BINDING COMPOUNDS | BIRC5, BIRC7, BIRC3 | ALDH1A1 2947/4885IMPDH2 1157/4885KDM4E 2792/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.