Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 17/20 | 0.55 |
| ▸ | MAPK13 | O15264 | 11/20 | 0.50 |
| ▸ | MAPK12 | P53778 | 11/20 | 0.50 |
| ▸ | MAPK11 | Q15759 | 11/20 | 0.50 |
| ▸ | GCGR | P47871 | 9/20 | 0.50 |
| ▸ | ALOX5 | P09917 | 4/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | CSNK1D | P48730 | 2/20 | 0.41 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.41 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.41 |
| ▸ | FRK | P42685 | 1/20 | 0.41 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4584932 | 0.85 | MAPK14 (0.46) | MAPK14MAPK13MAPK12MAPK11GCGR | |
| SCHEMBL7209158 | 0.81 | MAPK14 (0.62) | MAPK14MAPK13MAPK12MAPK11GCGR | |
| SCHEMBL4553347 | 0.79 | MAPK14 (0.76) | MAPK14MAPK13MAPK12MAPK11GCGR | |
| SCHEMBL7206018 | 0.79 | ALOX5 (0.64) | MAPK14MAPK13MAPK12MAPK11GCGR | |
| SCHEMBL4554967 | 0.77 | MAPK14 (0.62) | MAPK14MAPK13MAPK12MAPK11GCGR | |
| SCHEMBL13712660 | 0.76 | MAPK14 (0.83) | MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL4586521 | 0.76 | MAPK14 (0.51) | MAPK14MAPK13MAPK12MAPK11GCGR | |
| SCHEMBL4553295 | 0.74 | MAPK13 (0.58) | MAPK14MAPK13MAPK12MAPK11GCGR | |
| SCHEMBL4585131 | 0.72 | MAPK14 (0.62) | MAPK14MAPK13MAPK12MAPK11CSNK1D | |
| SCHEMBL4460400 | 0.71 | MAPK14 (1.00) | MAPK14MAPK13MAPK12MAPK11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0994870-A4 | NOVEL ARYLOXY SUBSTITUTED PYRIMIDINE IMIDAZOLE COMPOUNDS | SMITHKLINE BEECHAM (US) | 2002-10-23 | — | — | EP | claimed |
| EP-0994870-A1 | NOVEL ARYLOXY SUBSTITUTED PYRIMIDINE IMIDAZOLE COMPOUNDS | Smithkline Beecham (US) | 2000-04-26 | — | — | EP | claimed |
| WO-1998057966-A1 | NOVEL ARYLOXY SUBSTITUTED PYRIMIDINE IMIDAZOLE COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 1998-12-23 | — | — | WO | claimed |
| US-6610695-B1 | Prophylaxis or treatment of CSBP/RK/p38 kinase mediated disease | SMITHKLINE BEECHAM CORPORATION | 2003-08-26 | — | — | US | disclosed |
| EP-0994870-A4 | NOVEL ARYLOXY SUBSTITUTED PYRIMIDINE IMIDAZOLE COMPOUNDS | SMITHKLINE BEECHAM (US) | 2002-10-23 | — | — | EP | disclosed |
| EP-0994870-A1 | NOVEL ARYLOXY SUBSTITUTED PYRIMIDINE IMIDAZOLE COMPOUNDS | Smithkline Beecham (US) | 2000-04-26 | — | — | EP | disclosed |
| WO-1998057966-A1 | NOVEL ARYLOXY SUBSTITUTED PYRIMIDINE IMIDAZOLE COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 1998-12-23 | — | — | WO | disclosed |