Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 2/20 | 0.51 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | HTR1A | P08908 | 1/20 | 0.51 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.51 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.43 |
| ▸ | QDPR | P09417 | 2/20 | 0.43 |
| ▸ | KDR | P35968 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL7859752 | 0.82 | SLC6A4 (0.56) | HTR6SLC6A4HRH4 | |
| Bromide SCHEMBL7868021 | 0.81 | SLC6A4 (0.52) | HTR6SLC6A4QDPR | |
| SCHEMBL7496144 | 0.81 | HRH4 (0.46) | HTR6SLC6A4HRH4QDPR | |
| SCHEMBL6646297 | 0.81 | TNKS (0.51) | HTR6SLC6A4KDM4ELMNAPOLB | |
| SCHEMBL11864700 | 0.80 | QDPR (0.49) | LMNAHRH4QDPRKDR | |
| SCHEMBL7866268 | 0.79 | SLC6A4 (0.44) | HTR6SLC6A4KDM4ELMNAPOLB | |
| Bromide SCHEMBL7867418 | 0.77 | HRH4 (0.45) | SLC6A4HRH4 | |
| SCHEMBL7866398 | 0.77 | DRD2 (0.61) | HTR6HTR1AKDR | |
| Bromide SCHEMBL7859817 | 0.77 | HTR6 (0.50) | HTR6SLC6A4KDM4ELMNAPOLB | |
| SCHEMBL7214674 | 0.74 | DRD2 (0.42) | SLC6A4HTR1AHRH4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6608079-B1 | Activating serotonin-1F receptors, inhibiting neuronal protein extravasation, treating migraine | ELI LILLY AND COMPANY | 2003-08-19 | — | — | US | disclosed |
| EP-1196380-A2 | INDOLES AND INDAZOLES FOR THE TREATMENT OF MIGRAINE | NPS Allelix Corp. (CA) | 2002-04-17 | — | — | EP | disclosed |
| WO-2001005758-A2 | INDOLES AND INDAZOLES FOR THE TREATMENT OF MIGRAINE | NPS ALLELIX CORP. (CA) | 2001-01-25 | — | — | WO | disclosed |