Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 14/20 | 0.63 |
| ▸ | HTR1A | P08908 | 4/20 | 0.59 |
| ▸ | HTR1D | P28221 | 4/20 | 0.59 |
| ▸ | HTR1B | P28222 | 4/20 | 0.59 |
| ▸ | HTR7 | P34969 | 4/20 | 0.59 |
| ▸ | HTR2A | P28223 | 3/20 | 0.59 |
| ▸ | DRD2 | P14416 | 3/20 | 0.59 |
| ▸ | HTR2C | P28335 | 3/20 | 0.59 |
| ▸ | ADRA1B | P35368 | 3/20 | 0.59 |
| ▸ | DRD3 | P35462 | 3/20 | 0.59 |
| ▸ | HTR4 | Q13639 | 3/20 | 0.59 |
| ▸ | HTR2B | P41595 | 2/20 | 0.59 |
| ▸ | HTR1E | P28566 | 1/20 | 0.59 |
| ▸ | HTR1F | P30939 | 1/20 | 0.59 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.55 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.55 |
| ▸ | PFKFB3 | Q16875 | 2/20 | 0.55 |
| ▸ | PFKFB4 | Q16877 | 2/20 | 0.55 |
| ▸ | DRD1 | P21728 | 1/20 | 0.54 |
| ▸ | DRD4 | P21917 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10239970 | 0.79 | HTR6 (0.63) | HTR6HTR1AHTR1DHTR1BHTR7 | |
| Hydrochloric Acid SCHEMBL3153634 | 0.78 | HTR6 (0.62) | HTR6HTR1AHTR1DHTR1BHTR7 | |
| SCHEMBL6981823 | 0.77 | HTR6 (0.80) | HTR6HTR1AHTR1DHTR1BHTR7 | |
| SCHEMBL6972216 | 0.77 | HTR6 (0.80) | HTR6HTR1AHTR1DHTR1BHTR7 | |
| SCHEMBL3144856 | 0.77 | HTR6 (0.87) | HTR6HTR1AHTR1DHTR1BHTR7 | |
| SCHEMBL3157138 | 0.77 | HTR6 (0.72) | HTR6HTR1AHTR1DHTR1BHTR7 | |
| SCHEMBL3154082 | 0.77 | HTR6 (1.00) | HTR6HTR1AHTR1DHTR1BHTR7 | |
| SCHEMBL2905817 | 0.77 | HTR6 (0.75) | HTR6HTR1AHTR1DHTR1BHTR7 | |
| SCHEMBL3148659 | 0.76 | HTR6 (0.73) | HTR6HTR1AHTR1DHTR1BHTR7 | |
| SCHEMBL6980956 | 0.76 | HTR6 (0.77) | HTR6HTR1AHTR1DHTR1BHTR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0946539-A1 | SULPHONAMIDE DERIVATIVES, PROCESS FOR THEIR PREPARATION, AND THEIR USE AS MEDICAMENTS | SMITHKLINE BEECHAM PLC (GB) | 1999-10-06 | — | — | EP | claimed |
| WO-1998027081-A1 | SULPHONAMIDE DERIVATIVES, PROCESS FOR THEIR PREPARATION, AND THEIR USE AS MEDICAMENTS | SMITHKLINE BEECHAM PLC (GB) | 1998-06-25 | — | — | WO | claimed |
| US-20090005417-A1 | Substituted Indazolyl Sulfonamide and 2,3-Dihydro-Indolyl Sulfonamide Compounds, their Preparation and Use in Medicaments | LABORATORIOS DEL DR. ESTEVE S.A. (ES) | 2009-01-01 | — | — | US | disclosed |
| US-20090005417-A1 | Substituted Indazolyl Sulfonamide and 2,3-Dihydro-Indolyl Sulfonamide Compounds, their Preparation and Use in Medicaments | LABORATORIOS DEL DR. ESTEVE S.A. (ES) | 2009-01-01 | — | — | US | disclosed |
| US-6599904-B2 | 5-HT6 receptor antagonists are believed to be of potential use in the treatment of certain CNS disorders; cognitive memory enhancement | SMITHKLINE BEECHAM P.L.C. (GB) | 2003-07-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090005417-A1 | Substituted Indazolyl Sulfonamide and 2,3-Dihydro-Indolyl Sulfonamide Compounds, their Preparation and Use in Medicaments | HTR6, TPH2, HTR5A | HTR6 1/4885HTR1A 11/4885HTR1D 28/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.