Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERCC5 | P28715 | 1/20 | 0.37 |
| ▸ | FEN1 | P39748 | 1/20 | 0.37 |
| ▸ | DPP4 | P27487 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 3/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.33 |
| ▸ | LMNA | P02545 | 3/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | LSS | P48449 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | ATF4 | P18848 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7203316 | 0.78 | LSS (0.45) | ALDH1A1SMN1; SMN2MAPTL3MBTL1LMNA | |
| SCHEMBL7202897 | 0.74 | LSS (0.45) | DPP4KDM4EALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL27579928 | 0.72 | LSS (0.62) | SMN1; SMN2KCNH2MAPTL3MBTL1LMNA | |
| SCHEMBL1484789 | 0.72 | KDM4E (0.34) | KDM4EALDH1A1LMNA | |
| SCHEMBL6450860 | 0.72 | GAA (0.41) | ALDH1A1LMNAKMT2AGAALSS | |
| SCHEMBL6019234 | 0.71 | LSS (0.46) | SMN1; SMN2KCNH2MAPTL3MBTL1LMNA | |
| SCHEMBL6019239 | 0.71 | LSS (0.46) | SMN1; SMN2KCNH2MAPTL3MBTL1LMNA | |
| SCHEMBL6450196 | 0.68 | MGLL (0.47) | ALDH1A1SMN1; SMN2MAPTLMNAKMT2A | |
| SCHEMBL2544201 | 0.67 | GSK3B (0.50) | ERCC5FEN1KDM4EALDH1A1MAPT | |
| SCHEMBL3867134 | 0.64 | MEN1 (0.59) | ERCC5FEN1KDM4EALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1311475-A1 | NOVEL AMINOCYCLOHEXANE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2003-05-21 | — | — | EP | disclosed |
| WO-2002014267-A1 | NOVEL AMINOCYCLOHEXANE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2002-02-21 | — | — | WO | disclosed |