Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LSS | P48449 | 4/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.41 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.39 |
| ▸ | HSD11B2 | P80365 | 1/20 | 0.39 |
| ▸ | MCHR1 | Q99705 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | AGER | Q15109 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.35 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.34 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.34 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27579928 | 0.85 | LSS (0.62) | LSSL3MBTL1SMN1; SMN2MAPTLMNA | |
| SCHEMBL7203314 | 0.78 | ERCC5 (0.37) | LSSL3MBTL1SMN1; SMN2ALDH1A1GAA | |
| SCHEMBL4801608 | 0.77 | LSS (0.57) | LSSL3MBTL1PDK2HSD11B1HSD11B2 | |
| SCHEMBL4801605 | 0.77 | LSS (0.57) | LSSL3MBTL1PDK2HSD11B1HSD11B2 | |
| SCHEMBL7204638 | 0.75 | LSS (0.51) | LSSSMN1; SMN2KMT2APOLBMAPT | |
| SCHEMBL6019234 | 0.75 | LSS (0.46) | LSSL3MBTL1SMN1; SMN2POLBMAPT | |
| SCHEMBL6019239 | 0.75 | LSS (0.46) | LSSL3MBTL1SMN1; SMN2POLBMAPT | |
| SCHEMBL4804351 | 0.74 | LSS (0.59) | LSSL3MBTL1PDK2HSD11B1HSD11B2 | |
| SCHEMBL4804360 | 0.74 | LSS (0.59) | LSSL3MBTL1PDK2HSD11B1HSD11B2 | |
| SCHEMBL7202898 | 0.74 | LSS (0.69) | LSSL3MBTL1SMN1; SMN2MAPTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1311475-A1 | NOVEL AMINOCYCLOHEXANE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2003-05-21 | — | — | EP | disclosed |
| WO-2002014267-A1 | NOVEL AMINOCYCLOHEXANE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2002-02-21 | — | — | WO | disclosed |