Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LSS | P48449 | 4/20 | 0.45 |
| ▸ | DPP4 | P27487 | 1/20 | 0.36 |
| ▸ | ATF4 | P18848 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.32 |
| ▸ | PPARA | Q07869 | 1/20 | 0.31 |
| ▸ | ELANE | P08246 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 2/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | RAB9A | P51151 | 1/20 | 0.30 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7203539 | 0.83 | LSS (0.38) | LSSDPP4ATF4ALDH1A1KMT2A | |
| SCHEMBL7207244 | 0.81 | LSS (0.41) | LSSDPP4ATF4KMT2APPARA | |
| SCHEMBL7202898 | 0.81 | LSS (0.69) | LSSLMNAMAPTSMN1; SMN2L3MBTL1 | |
| SCHEMBL6447767 | 0.74 | LSS (0.41) | LSSALDH1A1KMT2AGAAMEN1 | |
| SCHEMBL7203314 | 0.74 | ERCC5 (0.37) | LSSDPP4ATF4ALDH1A1KDM4E | |
| SCHEMBL5024123 | 0.71 | SMN1; SMN2 (0.50) | DPP4ATF4ALDH1A1TDP1KMT2A | |
| SCHEMBL6018945 | 0.71 | ALDH1A1 (0.38) | DPP4ATF4ALDH1A1KMT2AMEN1 | |
| SCHEMBL6450196 | 0.68 | MGLL (0.47) | LSSALDH1A1KMT2AMEN1LMNA | |
| SCHEMBL28749452 | 0.68 | ATF4 (0.36) | LSSDPP4ATF4ALDH1A1KMT2A | |
| SCHEMBL27579928 | 0.68 | LSS (0.62) | LSSLMNAMAPTSMN1; SMN2L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1311475-A1 | NOVEL AMINOCYCLOHEXANE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2003-05-21 | — | — | EP | disclosed |
| WO-2002014267-A1 | NOVEL AMINOCYCLOHEXANE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2002-02-21 | — | — | WO | disclosed |