Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 10/20 | 0.51 |
| ▸ | MEN1 | O00255 | 8/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 8/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.51 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 3/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 3/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL620895 | 0.93 | RAB9A (0.48) | MAPTMEN1KMT2ACYP1A2CYP3A4 | |
| SCHEMBL6720595 | 0.88 | MAPT (0.45) | MAPTMEN1KMT2ACYP1A2CYP3A4 | |
| SCHEMBL6717398 | 0.86 | SIGMAR1 (0.52) | MAPTMEN1KMT2ACYP1A2CYP3A4 | |
| SCHEMBL6724396 | 0.84 | RAB9A (0.41) | MAPTMEN1KMT2ACYP1A2CYP3A4 | |
| SCHEMBL14862342 | 0.83 | MEN1 (0.43) | MAPTMEN1KMT2ACYP1A2CYP3A4 | |
| SCHEMBL6721212 | 0.83 | SMN1; SMN2 (0.46) | MAPTMEN1KMT2ACYP1A2CYP3A4 | |
| SCHEMBL6720838 | 0.83 | RAB9A (0.39) | MAPTMEN1KMT2ACYP1A2CYP3A4 | |
| SCHEMBL6727685 | 0.81 | ALDH1A1 (0.46) | MAPTMEN1KMT2ACYP1A2CYP3A4 | |
| SCHEMBL6727803 | 0.81 | SIGMAR1 (0.63) | SIGMAR1 | |
| SCHEMBL6720918 | 0.80 | MEN1 (0.51) | MAPTMEN1KMT2ACYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0705100-B1 | THERAPEUTIC SUBSTITUTED GUANIDINES | CENES LTD (GB) | 2003-07-30 | — | — | EP | claimed |
| US-6156741-A | Therapeutic substituted guanidines | CAMBRIDGE NEUROSCIENCE, INC. (US) | 2000-12-05 | — | — | US | claimed |
| EP-0918460-A1 | METHODS OF TREATMENT OF EYE TRAUMA AND DISORDERS | CAMBRIDGE NEUROSCIENCE, INC. (US) | 1999-06-02 | — | — | EP | claimed |
| WO-1999002145-A1 | COMBINATION DRUG THERAPIES COMPRISING AMINOGLYCOSIDE ANTIBIOTICS AND N,N'-DISUBSTITUTED GUANIDINES | CAMBRIDGE NEUROSCIENCE, INC. (US) | 1999-01-21 | — | — | WO | claimed |
| WO-1998004131-A1 | METHODS OF TREATMENT OF EYE TRAUMA AND DISORDERS | CAMBRIDGE NEUROSCIENCE, INC. (US) | 1998-02-05 | — | — | WO | claimed |
| CN-1126434-A | Therapeutic substituted guanidines | CAMBRIDGE NEUROSCIENCE INC (US) | 1996-07-10 | — | — | CN | claimed |
| WO-1999002145-A1 | COMBINATION DRUG THERAPIES COMPRISING AMINOGLYCOSIDE ANTIBIOTICS AND N,N'-DISUBSTITUTED GUANIDINES | CAMBRIDGE NEUROSCIENCE, INC. (US) | 1999-01-21 | — | — | WO | disclosed |
| CN-1126434-A | Therapeutic substituted guanidines | CAMBRIDGE NEUROSCIENCE INC (US) | 1996-07-10 | — | — | CN | disclosed |