Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | CASP3 | P42574 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 3/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | CA12 | O43570 | 1/20 | 0.31 |
| ▸ | CA1 | P00915 | 1/20 | 0.31 |
| ▸ | CA2 | P00918 | 1/20 | 0.31 |
| ▸ | CA9 | Q16790 | 1/20 | 0.31 |
| ▸ | RECQL | P46063 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8903951 | 0.86 | CYP3A4 (0.46) | CYP3A4POLBKDM4EALDH1A1CASP3 | |
| SCHEMBL288566 | 0.86 | CYP3A4 (0.46) | CYP3A4POLBKDM4EALDH1A1CASP3 | |
| SCHEMBL29044522 | 0.84 | CYP3A4 (0.44) | CYP3A4POLBKDM4EALDH1A1CASP3 | |
| SCHEMBL22337578 | 0.83 | CA12 (0.31) | CA12CA1CA2CA9 | |
| SCHEMBL723082 | 0.77 | POLB (0.43) | CYP3A4POLBKDM4EALDH1A1CASP3 | |
| SCHEMBL23193312 | 0.77 | CYP3A4 (0.38) | CYP3A4POLBKDM4EALDH1A1CASP3 | |
| SCHEMBL509098 | 0.73 | — | — | |
| SCHEMBL16116448 | 0.72 | — | — | |
| SCHEMBL9907094 | 0.70 | CYP3A4 (0.44) | CYP3A4POLBALDH1A1CASP3CYP1A2 | |
| SCHEMBL508459 | 0.70 | FAAH (0.40) | POLBCA12CA1CA2CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 52 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2625217-B1 | CHAIN-EXTENDED POLYSILOXANE CROSSLINKERS WITH DANGLING HYDROPHILIC POLYMER CHAINS | NOVARTIS AG (CH) | 2018-07-04 | — | — | EP | claimed |
| EP-2625218-B1 | WATER-PROCESSABLE SILICONE-CONTAINING PREPOLYMERS AND USES THEREOF | NOVARTIS AG (CH) | 2018-04-25 | — | — | EP | claimed |
| US-9921340-B2 | Water-processable silicone-containing prepolymers and uses thereof | NOVARTIS AG (CH) | 2018-03-20 | — | — | US | claimed |
| US-20160033683-A1 | WATER-PROCESSABLE SILICONE-CONTAINING PREPOLYMERS AND USES THEREOF | ALCON INC. (CH) | 2016-02-04 | — | — | US | claimed |
| US-9187601-B2 | Water-processable silicone-containing prepolymers and uses thereof | NOVARTIS AG (CH) | 2015-11-17 | — | — | US | claimed |
| EP-2931790-A1 | ACTINICALLY-CROSSLINKABLE AMPHIPHILIC PREPOLYMERS | Novartis AG (CH) | 2015-10-21 | — | — | EP | claimed |
| US-8835525-B2 | Chain-extended polysiloxane crosslinkers with dangling hydrophilic polymer chains | NOVARTIS AG (CH) | 2014-09-16 | — | — | US | claimed |
| US-20140171543-A1 | ACTINICALLY-CROSSLINKABLE AMPHIPHILIC PREPOLYMERS | NOVARTIS AG (CH) | 2014-06-19 | — | — | US | claimed |
| WO-2014093756-A1 | ACTINICALLY-CROSSLINKABLE AMPHIPHILIC PREPOLYMERS | NOVARTIS AG (CH) | 2014-06-19 | — | — | WO | claimed |
| EP-2625217-A1 | CHAIN-EXTENDED POLYSILOXANE CROSSLINKERS WITH DANGLING HYDROPHILIC POLYMER CHAINS | Novartis AG (CH) | 2013-08-14 | — | — | EP | claimed |
| EP-2625218-A1 | WATER-PROCESSABLE SILICONE-CONTAINING PREPOLYMERS AND USES THEREOF | Novartis AG (CH) | 2013-08-14 | — | — | EP | claimed |
| US-20120088844-A1 | CHAIN-EXTENDED POLYSILOXANE CROSSLINKERS WITH DANGLING HYDROPHILIC POLYMER CHAINS | ALCON INC. (CH) | 2012-04-12 | — | — | US | claimed |
| US-20120088861-A1 | WATER-PROCESSABLE SILICONE-CONTAINING PREPOLYMERS AND USES THEREOF | ALCON INC. (CH) | 2012-04-12 | — | — | US | claimed |
| WO-2012047964-A1 | CHAIN-EXTENDED POLYSILOXANE CROSSLINKERS WITH DANGLING HYDROPHILIC POLYMER CHAINS | NOVARTIS AG (CH) | 2012-04-12 | — | — | WO | claimed |
| WO-2012047969-A1 | WATER-PROCESSABLE SILICONE-CONTAINING PREPOLYMERS AND USES THEREOF | NOVARTIS AG (CH) | 2012-04-12 | — | — | WO | claimed |
| US-8124668-B2 | Silicone-containing ocular lens material with high safety and preparing method thereof | MENICON CO., LTD. (JP) | 2012-02-28 | — | — | US | claimed |
| US-20060142410-A1 | Silicone-containing ocular lens material with high safety and preparing method thereof | MENICON CO., LTD. (JP) | 2006-06-29 | — | — | US | claimed |
| EP-1582910-A1 | HIGHLY SAFE SILICONE-CONTAINING MATERIAL FOR OCULAR LENS AND PROCESS FOR PRODUCING THE SAME | MENICON CO., LTD. (JP) | 2005-10-05 | — | — | EP | claimed |
| EP-2625217-B1 | CHAIN-EXTENDED POLYSILOXANE CROSSLINKERS WITH DANGLING HYDROPHILIC POLYMER CHAINS | NOVARTIS AG (CH) | 2018-07-04 | — | — | EP | disclosed |
| EP-1582910-A1 | HIGHLY SAFE SILICONE-CONTAINING MATERIAL FOR OCULAR LENS AND PROCESS FOR PRODUCING THE SAME | MENICON CO., LTD. (JP) | 2005-10-05 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120088844-A1 | CHAIN-EXTENDED POLYSILOXANE CROSSLINKERS WITH DANGLING HYDROPHILIC POLYMER CHAINS | HACD2, HACD3, PCNA | CYP3A4 1461/4885POLB 775/4885KDM4E 3476/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.