Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 3/20 | 0.36 |
| ▸ | PDE10A | Q9Y233 | 8/20 | 0.35 |
| ▸ | PDE4A | P27815 | 1/20 | 0.34 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.34 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.33 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.33 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.32 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.32 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.32 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.32 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.32 |
| ▸ | AKR1C2 | P52895 | 2/20 | 0.32 |
| ▸ | GFPT1 | Q06210 | 1/20 | 0.32 |
| ▸ | CDC42 | P60953 | 1/20 | 0.32 |
| ▸ | RAC1 | P63000 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4812337 | 0.76 | PTGS2 (0.42) | PDE5APDE10ASOS1PTGS2PTGS1 | |
| SCHEMBL4811242 | 0.71 | PDE10A (0.45) | PDE5APDE10AAKR1C3AKR1C2TSHR | |
| SCHEMBL4813656 | 0.71 | PDE10A (0.45) | PDE5APDE10AAKR1C3AKR1C2TSHR | |
| Lithium SCHEMBL4813676 | 0.69 | PDE10A (0.45) | PDE5APDE10AAKR1C3AKR1C2TSHR | |
| Lithium SCHEMBL4811254 | 0.69 | PDE10A (0.45) | PDE5APDE10AAKR1C3AKR1C2TSHR | |
| SCHEMBL5745712 | 0.66 | GFPT1 (0.45) | PIM3SOS1GFPT1TSHR | |
| Lithium Ion SCHEMBL4811247 | 0.64 | PDE10A (0.44) | PDE5APDE10ATSHR | |
| Lithium Ion SCHEMBL4813660 | 0.64 | PDE10A (0.44) | PDE5APDE10ATSHR | |
| SCHEMBL29702221 | 0.63 | LRRK2 (0.48) | PDE5APDE10APDE4APDE4DPIM3 | |
| SCHEMBL6732044 | 0.63 | PDE4A (0.41) | PDE10APDE4APDE4DGFPT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20030114469-A1 | Combinations | COHEN DAVID SAUL (US) | 2003-06-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030114469-A1 | Combinations | GPR119, SLC5A1, HMGCR | PDE5A 16/4885PDE10A 218/4885PDE4A 140/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.