Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.42 |
| ▸ | MEN1 | O00255 | 4/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
| ▸ | ALOX5 | P09917 | 7/20 | 0.42 |
| ▸ | EGFR | P00533 | 2/20 | 0.40 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.39 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | TUBB1 | Q9H4B7 | 1/20 | 0.38 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.38 |
| ▸ | ABL1 | P00519 | 1/20 | 0.37 |
| ▸ | BCR | P11274 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | USP2 | O75604 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7166657 | 0.91 | TRPM8 (0.42) | MAPTKMT2AMEN1ATMALOX5 | |
| SCHEMBL4483001 | 0.85 | KMT2A (0.46) | MAPTKMT2AMEN1ALOX5EGFR | |
| SCHEMBL7156759 | 0.85 | ADORA2A (0.39) | MAPTKMT2AMEN1ATMEGFR | |
| SCHEMBL7205277 | 0.83 | SLC16A3 (0.40) | MAPTKMT2AMEN1ATMEGFR | |
| SCHEMBL4486790 | 0.79 | KMT2A (0.45) | MAPTKMT2AMEN1ALOX5EGFR | |
| SCHEMBL4487336 | 0.74 | ALDH1A1 (0.47) | MAPTKMT2AMEN1KDM4EPKM | |
| SCHEMBL4483009 | 0.72 | EGFR (0.58) | MAPTKMT2AMEN1ATMEGFR | |
| SCHEMBL4483014 | 0.72 | EGFR (0.58) | MAPTKMT2AMEN1ATMEGFR | |
| SCHEMBL4418574 | 0.71 | EGFR (0.49) | MAPTKMT2AMEN1ATMALOX5 | |
| SCHEMBL14381045 | 0.71 | ABL1 (0.50) | MAPTKMT2AMEN1ATMALOX5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2003531133-A | — | — | 2003-10-21 | — | — | JP | claimed |
| EP-1272457-A2 | COMPOUNDS FOR MODULATING CELL PROLIFERATION | HSC Research and Development Limited Partnership (CA) | 2003-01-08 | — | — | EP | claimed |
| WO-2001079158-A2 | COMPOUNDS FOR MODULATING CELL PROLIFERATION | HSC RESEARCH AND DEVELOPMENT LIMITED PARTNERSHIP (CA) | 2001-10-25 | — | — | WO | claimed |