Known targets — ChEMBL curated mechanism
KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2
The experimentally established mechanism targets of Biphenyl. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | WDR5 | P61964 | 1/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.56 |
| ▸ | PRSS1 | P07477 | 2/20 | 0.56 |
| ▸ | PRSS2 | P07478 | 2/20 | 0.56 |
| ▸ | PRSS3 | P35030 | 2/20 | 0.56 |
| ▸ | F2 | P00734 | 1/20 | 0.52 |
| ▸ | F10 | P00742 | 1/20 | 0.52 |
| ▸ | F12 | P00748 | 1/20 | 0.52 |
| ▸ | F7 | P08709 | 1/20 | 0.52 |
| ▸ | F3 | P13726 | 1/20 | 0.52 |
| ▸ | PKM | P14618 | 1/20 | 0.52 |
| ▸ | BLM | P54132 | 1/20 | 0.50 |
| ▸ | C1S | P09871 | 1/20 | 0.48 |
| ▸ | RECQL | P46063 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | MMP3 | P08254 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Biphenyl SCHEMBL212324 | 0.97 | WDR5 (0.67) | WDR5ALDH1A1PRSS1PRSS2PRSS3 | |
| Biphenyl SCHEMBL10648446 | 0.94 | WDR5 (0.64) | WDR5ALDH1A1PRSS1PRSS2PRSS3 | |
| Biphenyl SCHEMBL9113005 | 0.94 | WDR5 (0.64) | WDR5ALDH1A1PRSS1PRSS2PRSS3 | |
| Biphenyl SCHEMBL2387223 | 0.94 | WDR5 (0.64) | WDR5ALDH1A1PRSS1PRSS2PRSS3 | |
| Biphenyl SCHEMBL27879827 | 0.87 | NQO2 (0.53) | WDR5ALDH1A1PRSS1PRSS2PRSS3 | |
| Biphenyl SCHEMBL28594776 | 0.85 | WDR5 (0.61) | WDR5ALDH1A1PRSS1PRSS2PRSS3 | |
| Biphenyl SCHEMBL2256875 | 0.84 | NQO2 (0.55) | WDR5ALDH1A1PRSS1PRSS2PRSS3 | |
| Biphenyl SCHEMBL28765729 | 0.84 | WDR5 (0.54) | WDR5ALDH1A1PRSS1PRSS2PRSS3 | |
| Biphenyl SCHEMBL1815228 | 0.84 | WDR5 (0.54) | WDR5ALDH1A1PRSS1PRSS2PRSS3 | |
| Biphenyl SCHEMBL28438673 | 0.80 | WDR5 (0.86) | WDR5ALDH1A1PRSS1PRSS2PRSS3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 89 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2990436-B1 | RUBBER COMPOSITION PREPARED WITH PRE-TREATED SILICA AND TIRE | GOODYEAR TIRE & RUBBER (US) | 2018-08-01 | — | — | EP | claimed |
| US-20160264768-A1 | RUBBER PREPARED WITH PRE-TREATED PRECIPITATED SILICA AND TIRE WITH COMPONENT | GOODYEAR TIRE & RUBBER COMPANY, THE | 2016-09-15 | — | — | US | claimed |
| EP-2990436-A1 | RUBBER COMPOSITION PREPARED WITH PRE-TREATED SILICA AND TIRE | The Goodyear Tire & Rubber Company (US) | 2016-03-02 | — | — | EP | claimed |
| US-20160053071-A1 | RUBBER PREPARED WITH PRE-TREATED PRECIPITATED SILICA AND TIRE WITH COMPONENT | GOODYEAR TIRE & RUBBER COMPANY, THE | 2016-02-25 | — | — | US | claimed |
| US-11547174-B2 | Footwear and rubber sole containing dual silica moieties | THE GOODYEAR TIRE & RUBBER COMPANY (US) | 2023-01-10 | — | — | US | disclosed |
| EP-3034328-B1 | RUBBER COMPOSITION CONTAINING TWO DIFFERENTELY FUNCTIONALISED SBR | GOODYEAR TIRE & RUBBER (US) | 2022-09-14 | — | — | EP | disclosed |
| EP-3686031-B1 | RUBBER COMPOSITION CONTAINING A SPECIALIZED STYRENE/BUTADIENE ELASTOMER, VEGETABLE OIL AND A TRACTION RESIN | GOODYEAR TIRE & RUBBER (US) | 2022-03-30 | — | — | EP | disclosed |
| US-10961373-B2 | Tire with tread of carbon black reinforced rubber composition containing specialized styrene/butadiene elastomer | THE GOODYEAR TIRE & RUBBER COMPANY (US) | 2021-03-30 | — | — | US | disclosed |
| EP-3418073-B1 | RUBBER COMPOSITION CONTAINING STYRENE/BUTADIENE ELASTOMER AND SILICA REINFORCEMENT AND TIRE | GOODYEAR TIRE & RUBBER (US) | 2020-08-05 | — | — | EP | disclosed |
| EP-3686031-A1 | RUBBER COMPOSITION CONTAINING A SPECIALIZED STYRENE/BUTADIENE ELASTOMER, VEGETABLE OIL AND A TRACTION RESIN | The Goodyear Tire & Rubber Company (US) | 2020-07-29 | — | — | EP | disclosed |
| US-20200231787-A1 | TIRE WITH COMPONENT OF SILICA REINFORCED RUBBER COMPOSITION CONTAINING SPECIALIZED STYRENE/BUTADIENE ELASTOMER AND VEGETABLE OIL AND TRACTION RESIN | GOODYEAR TIRE & RUBBER COMPANY, THE | 2020-07-23 | — | — | US | disclosed |
| US-20200146394-A1 | FOOTWEAR AND RUBBER SOLE CONTAINING DUAL SILICA MOIETIES | THE GOODYEAR TIRE & RUBBER COMPANY | 2020-05-14 | — | — | US | disclosed |
| US-20120053286-A1 | PREPARATION AND USE OF SILICA REINFORCED RUBBER COMPOSITION FOR TRUCK TIRE TREAD | GOODYEAR TIRE & RUBBER COMPANY, THE | 2012-03-01 | — | — | US | disclosed |
| US-7956146-B2 | Tire with tread of polybutadiene rubber | THE GOODYEAR TIRE & RUBBER COMPANY (US) | 2011-06-07 | — | — | US | disclosed |
| EP-2223928-A1 | Functionalized lignin, rubber containing functionalized lignin and products containing such rubber composition | The Goodyear Tire & Rubber Company (US) | 2010-09-01 | — | — | EP | disclosed |
| US-20100216939-A1 | TIRE WITH TREAD OF POLYBUTADIENE RUBBER | GOODYEAR TIRE & RUBBER COMPANY, THE | 2010-08-26 | — | — | US | disclosed |
| EP-2221195-A1 | Tire with a rubber composition and a tread of polybutadiene rubber | The Goodyear Tire & Rubber Company (US) | 2010-08-25 | — | — | EP | disclosed |
| US-20100204368-A1 | FUNCTIONALIZED LIGNIN, RUBBER CONTAINING FUNCTIONALIZED LIGNIN AND PRODUCTS CONTAINING SUCH RUBBER COMPOSITION | NATIONAL TECHNOLOGY & ENGINEERING SOLUTIONS OF SANDIA, LLC | 2010-08-12 | — | — | US | disclosed |
| US-7473728-B2 | Dual phase rubber composition and tire with nanocomposite-containing sidewall thereof | THE GOODYEAR TIRE & RUBBER COMPANY (US) | 2009-01-06 | — | — | US | disclosed |
| US-20060135671-A1 | Dual phase rubber composition and tire with nanocomposite-containing sidewall thereof | GOODYEAR TIRE & RUBBER COMPANY, THE | 2006-06-22 | — | — | US | disclosed |