Biphenyl

Biphenyl

SCHEMBL1815228

CCO.N=C(N)N.c1ccc(-c2ccccc2)cc1

nearest known ligand 0.54

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2

The experimentally established mechanism targets of Biphenyl. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
WDR5 P61964 1/20 0.54
PRSS1 P07477 2/20 0.48
PRSS2 P07478 2/20 0.48
PRSS3 P35030 2/20 0.48
ALDH1A1 P00352 1/20 0.45
LMNA P02545 1/20 0.44
F2 P00734 1/20 0.44
F10 P00742 1/20 0.44
F12 P00748 1/20 0.44
F7 P08709 1/20 0.44
F3 P13726 1/20 0.44
PKM P14618 1/20 0.44
SMN1; SMN2 Q16637 2/20 0.43
L3MBTL1 Q9Y468 2/20 0.43
MAPT P10636 1/20 0.43
BLM P54132 1/20 0.42
IDO1 P14902 3/20 0.41
NOS3 P29474 1/20 0.41
NOS1 P29475 1/20 0.41
NOS2 P35228 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Biphenyl SCHEMBL80316 0.87 ALDH1A1 (0.60) ALDH1A1LMNASMN1; SMN2L3MBTL1MAPT
Biphenyl SCHEMBL8855942 0.87 ALDH1A1 (0.60) ALDH1A1LMNASMN1; SMN2L3MBTL1MAPT
Biphenyl SCHEMBL212324 0.87 WDR5 (0.67) WDR5PRSS1PRSS2PRSS3ALDH1A1
Biphenyl SCHEMBL28026828 0.84 ALDH1A1 (0.56) ALDH1A1LMNASMN1; SMN2L3MBTL1MAPT
Biphenyl SCHEMBL2387223 0.84 WDR5 (0.64) WDR5PRSS1PRSS2PRSS3ALDH1A1
Biphenyl SCHEMBL720475 0.84 WDR5 (0.64) WDR5PRSS1PRSS2PRSS3ALDH1A1
Biphenyl SCHEMBL9113005 0.84 WDR5 (0.64) WDR5PRSS1PRSS2PRSS3ALDH1A1
Biphenyl SCHEMBL10648446 0.84 WDR5 (0.64) WDR5PRSS1PRSS2PRSS3ALDH1A1
Benzene SCHEMBL28326043 0.84 TSHR (0.43) PRSS1PRSS2PRSS3ALDH1A1LMNA
Biphenyl SCHEMBL28594776 0.81 WDR5 (0.61) WDR5PRSS1PRSS2PRSS3ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2496393-B1 METHOD FOR MAKING PROTECTIVE GARMENTS A T G CEYLON PRIVATE LTD (LK) 2019-07-17 EP disclosed
EP-3023538-B1 ANTI-PERSPIRANT GLOVE ATG CEYLON PRIVATE LTD (LK) 2018-10-31 EP disclosed
US-20180171541-A1 ANTI-PERSPIRANT GLOVE A T G CEYLON (PRIVATE) LIMITED (LK) 2018-06-21 US disclosed
US-9890497-B2 Anti-perspirant glove A T G CEYLON (PRIVATE) LIMITED (LK) 2018-02-13 US disclosed
EP-3023538-A1 ANTI-PERSPIRANT GLOVE ATG Ceylon (Private) Limited (LK) 2016-05-25 EP disclosed
US-9061453-B2 Protective garments and materials therefor ATG CEYLON (PRIVATE) LIMITED (LK) 2015-06-23 US disclosed
US-20150082508-A1 ANTI-PERSPIRANT GLOVE A T G CEYLON (PRIVATE) LIMITED (LK) 2015-03-26 US disclosed
US-8894896-B2 Polymeric garment material A T G CEYLON (PRIVATE) LIMITED (LK) 2014-11-25 US disclosed
EP-2496393-A1 PROTECTIVE GARMENTS AND MATERIALS THEREFOR A T G Ceylon (Private) Limited (LK) 2012-09-12 EP disclosed
WO-2011051727-A1 PROTECTIVE GARMENTS AND MATERIALS THEREFOR ATG CEYLON (PRIVATE) LIMITED (LK) 2011-05-05 WO disclosed
US-20110099689-A1 PROTECTIVE GARMENTS AND MATERIALS THEREFOR ATG CEYLON (PRIVATE) LIMITED (LK) 2011-05-05 US disclosed
EP-1852548-B1 Polymeric garment material A T G CEYLON PRIVATE LTD (LK) 2009-12-16 EP disclosed
EP-1608808-B1 Verfahren zur Herstellung eines polymeren Bekleidungsstoffes JOHN WARD CEYLON PRIVATE LTD (LK) 2008-01-23 EP disclosed
EP-1852548-A2 Polymeric garment material John Ward Ceylon (Private) Limited (LK) 2007-11-07 EP disclosed
US-20060189240-A1 Polymeric garment material A T G CEYLON (PRIVATE) LIMITED (LK) 2006-08-24 US disclosed
EP-1608808-A1 POLYMERIC GARMENT MATERIAL John Ward Ceylon (Private) Limited (LK) 2005-12-28 EP disclosed
WO-2005088005-A1 POLYMERIC GARMENT MATERIAL JOHN WARD CEYLON (PRIVATE) LIMITED (LK) 2005-09-22 WO disclosed