Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 15/20 | 0.44 |
| ▸ | BRAF | P15056 | 3/20 | 0.44 |
| ▸ | TNNI3K | Q59H18 | 3/20 | 0.44 |
| ▸ | KIT | P10721 | 1/20 | 0.41 |
| ▸ | EGFR | P00533 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL7206426 | 0.99 | KDR (0.43) | KDRBRAFTNNI3KKITEGFR | |
| SCHEMBL7207079 | 0.91 | KDR (0.44) | KDRKITEGFR | |
| Hydrochloric Acid SCHEMBL7210078 | 0.90 | KDR (0.43) | KDRKITEGFR | |
| SCHEMBL7205058 | 0.88 | KDR (0.42) | KDREGFR | |
| SCHEMBL8501793 | 0.88 | KDR (0.44) | KDREGFR | |
| Hydrochloric Acid SCHEMBL7209534 | 0.88 | KDR (0.42) | KDREGFR | |
| Hydrochloric Acid SCHEMBL8501905 | 0.88 | KDR (0.43) | KDREGFR | |
| Hydrochloric Acid SCHEMBL7212126 | 0.85 | KIT (0.52) | KDRBRAFTNNI3KKITEGFR | |
| SCHEMBL7210197 | 0.84 | FBP1 (0.51) | KDR | |
| SCHEMBL7205577 | 0.84 | KDR (0.46) | KDREGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0912557-B1 | OXINDOLE DERIVATIVES | ASTRAZENECA AB (SE) | 2003-07-09 | — | — | EP | disclosed |
| US-6265411-B1 | ANGIOGENESIS INHIBITOR | ZENECA LIMITED (GB) | 2001-07-24 | — | — | US | disclosed |
| EP-0912557-A1 | OXINDOLE DERIVATIVES | ZENECA LIMITED (GB) | 1999-05-06 | — | — | EP | disclosed |
| WO-1997042187-A1 | OXINDOLE DERIVATIVES | ZENECA LIMITED (GB) | 1997-11-13 | — | — | WO | disclosed |