Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | MAPK14 | Q16539 | 12/20 | 0.39 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.38 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.37 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.35 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.35 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7205342 | 0.88 | MAPK14 (0.42) | MAPK14ALOX5MAPK13MAPK12MAPK11 | |
| SCHEMBL7202369 | 0.85 | MAPT (0.41) | MAPTL3MBTL1MAPK14ALOX5PDE10A | |
| SCHEMBL4584148 | 0.80 | ALOX5 (0.58) | MAPK14ALOX5MAPK13MAPK12MAPK11 | |
| SCHEMBL7205220 | 0.73 | MAPT (0.40) | MAPTL3MBTL1MAPK14PDE10A | |
| SCHEMBL7208451 | 0.72 | MAPK14 (0.40) | MAPTL3MBTL1MAPK14ALOX5MAPK13 | |
| SCHEMBL4585785 | 0.68 | ALOX5 (0.64) | MAPK14ALOX5MAPK13MAPK12MAPK11 | |
| SCHEMBL7805607 | 0.67 | MAPK14 (0.49) | MAPTL3MBTL1MAPK14 | |
| SCHEMBL7206018 | 0.66 | ALOX5 (0.64) | MAPK14ALOX5MAPK13MAPK12MAPK11 | |
| SCHEMBL6620610 | 0.65 | MAPK14 (0.54) | MAPTL3MBTL1MAPK14PDE10A | |
| SCHEMBL7201822 | 0.65 | MAPK14 (0.47) | MAPTL3MBTL1MAPK14ALOX5MAPK13 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6610695-B1 | Prophylaxis or treatment of CSBP/RK/p38 kinase mediated disease | SMITHKLINE BEECHAM CORPORATION | 2003-08-26 | — | — | US | disclosed |
| EP-0994870-A4 | NOVEL ARYLOXY SUBSTITUTED PYRIMIDINE IMIDAZOLE COMPOUNDS | SMITHKLINE BEECHAM (US) | 2002-10-23 | — | — | EP | disclosed |
| EP-0994870-A1 | NOVEL ARYLOXY SUBSTITUTED PYRIMIDINE IMIDAZOLE COMPOUNDS | Smithkline Beecham (US) | 2000-04-26 | — | — | EP | disclosed |
| WO-1998057966-A1 | NOVEL ARYLOXY SUBSTITUTED PYRIMIDINE IMIDAZOLE COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 1998-12-23 | — | — | WO | disclosed |