Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 8/20 | 0.64 |
| ▸ | MAPK14 | Q16539 | 14/20 | 0.50 |
| ▸ | MAPK13 | O15264 | 8/20 | 0.49 |
| ▸ | MAPK12 | P53778 | 8/20 | 0.49 |
| ▸ | MAPK11 | Q15759 | 8/20 | 0.49 |
| ▸ | GCGR | P47871 | 7/20 | 0.49 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.45 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.45 |
| ▸ | FRK | P42685 | 1/20 | 0.45 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.45 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.45 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.45 |
| ▸ | GSK3B | P49841 | 1/20 | 0.45 |
| ▸ | PTK6 | Q13882 | 1/20 | 0.45 |
| ▸ | PRKD2 | Q9BZL6 | 1/20 | 0.45 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7209158 | 0.84 | MAPK14 (0.62) | ALOX5MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL4584148 | 0.83 | ALOX5 (0.58) | ALOX5MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL4552013 | 0.79 | ALOX5 (1.00) | ALOX5MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL7209162 | 0.79 | MAPK14 (0.55) | ALOX5MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL13712660 | 0.75 | MAPK14 (0.83) | MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL4565990 | 0.75 | ALOX5 (1.00) | ALOX5MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL4585785 | 0.74 | ALOX5 (0.64) | ALOX5MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL2650007 | 0.73 | MAPK14 (0.81) | ALOX5MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL4585131 | 0.72 | MAPK14 (0.62) | MAPK14MAPK13MAPK12MAPK11MAPK9 | |
| SCHEMBL9194658 | 0.70 | MAPK13 (0.67) | ALOX5MAPK14MAPK13MAPK12MAPK11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6610695-B1 | Prophylaxis or treatment of CSBP/RK/p38 kinase mediated disease | SMITHKLINE BEECHAM CORPORATION | 2003-08-26 | — | — | US | disclosed |
| EP-0994870-A4 | NOVEL ARYLOXY SUBSTITUTED PYRIMIDINE IMIDAZOLE COMPOUNDS | SMITHKLINE BEECHAM (US) | 2002-10-23 | — | — | EP | disclosed |
| EP-0994870-A1 | NOVEL ARYLOXY SUBSTITUTED PYRIMIDINE IMIDAZOLE COMPOUNDS | Smithkline Beecham (US) | 2000-04-26 | — | — | EP | disclosed |
| WO-1998057966-A1 | NOVEL ARYLOXY SUBSTITUTED PYRIMIDINE IMIDAZOLE COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 1998-12-23 | — | — | WO | disclosed |